KPNA4, karyopherin subunit alpha 4

KPNA4, karyopherin subunit alpha 4

• The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

• Gene Synonyms (IPOA3, QIP1, SRP3, importin subunit alpha-3, importin alpha Q1, importin subunit alpha-4, karyopherin alpha 4 (importin alpha 3),)
• NCBI Gene ID: 3840
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00629
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

karyopherin subunit alpha 4 interacts with:

• actin related protein 1A
  actin related protein 1B
  activation induced cytidine deaminase
  activator of HSP90 ATPase activity 1
  antigen identified by monoclonal antibody Ki 67
  armadillo repeat containing 8
  BCL6 corepressor
  CCCTC-binding factor
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 6B
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chromobox 5
  cilia and flagella associated protein 20
  CTD small phosphatase like 2
  cullin 3
  cullin 4B
  cysteine and histidine rich 1
  elongation factor Tu GTP binding domain containing 2
  exonuclease 1
  family with sequence similarity 50 member B
  GTF2I repeat domain containing 1
  heat shock protein 90 beta family member 1
  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
  immediate early response 2
  importin 9
  kinesin family member C1
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  lamin B1
  ligand dependent nuclear receptor corepressor
  lin-28 homolog A
  lysine acetyltransferase 5
  metastasis associated 1
  methionine adenosyltransferase 2B
  methyl-CpG binding domain protein 5
  methyl-CpG binding protein 2
  methylphosphate capping enzyme
  minichromosome maintenance complex component 4
  MRG domain binding protein
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 7B
  neurotrophic receptor tyrosine kinase 3
  NHS-like 1
  NK2 homeobox 1
  nuclear cap binding protein subunit 1
  nuclear cap binding protein subunit 2
  nuclear cap binding protein subunit 2
  nuclear cap binding subunit 3
  nucleoporin 107
  nucleoporin 107
  nucleoporin 153
  nucleoporin 50
  nucleoporin 98
  nucleus accumbens associated 1
  par-3 family cell polarity regulator
  PHD finger protein 20 like 1
  phospholipase A2 activating protein
  PML nuclear body scaffold
  pre-mRNA processing factor 8
  protein phosphatase 1 catalytic subunit gamma
  pyrin and HIN domain family member 1
  pyruvate carboxylase
  Rac family small GTPase 1
  RAN binding protein 2
  RAN, member RAS oncogene family
  RecQ like helicase
  RecQ like helicase 4
  regulator of chromosome condensation 1
  RELA proto-oncogene, NF-kB subunit
  sclerostin
  SEC63 homolog, protein translocation regulator
  Shoc2, leucine rich repeat scaffold protein
  SRY-box transcription factor 2
  SUMO specific peptidase 2
  transglutaminase 2
  tripartite motif containing 28
  tripartite motif containing 3
  tumor protein p53
  tumor protein p63
  ubiquinol-cytochrome c reductase core protein 2
  unk zinc finger
  WT1 transcription factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.