LCP2, lymphocyte cytosolic protein 2

LCP2, lymphocyte cytosolic protein 2

• This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]

• Gene Synonyms (SLP-76, SLP76, lymphocyte cytosolic protein 2, 76 kDa tyrosine phosphoprotein, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein,)
• NCBI Gene ID: 3937
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13094
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lymphocyte cytosolic protein 2 interacts with:

• B cell linker
  cytokine dependent hematopoietic cell linker
  ELOVL fatty acid elongase 6
  FMR1 autosomal homolog 2
  FYN binding protein
  GRB2 related adaptor protein 2
  lamin A/C
  ligand of numb-protein X 1
  linker for activation of T cells
  LYN proto-oncogene, Src family tyrosine kinase
  mitogen-activated protein kinase kinase kinase kinase 1
  NCK adaptor protein 1
  NCK adaptor protein 2
  phosphoinositide-3-kinase regulatory subunit 1
  phospholipase C gamma 1
  phospholipase C gamma 2
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  PML-RARA regulated adaptor molecule 1
  praja ring finger ubiquitin ligase 1
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type C
  SH2 domain containing adaptor protein B
  SH3 domain containing GRB2 like 2, endophilin A1
  SH3 domain containing ring finger 1
  SHC adaptor protein 1
  signal transducing adaptor molecule 2
  spleen associated tyrosine kinase
  T cell receptor associated transmembrane adaptor 1
  TXK tyrosine kinase
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosine kinase non receptor 2
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 3
  WASP actin nucleation promoting factor
  Y-box binding protein 1
  zeta chain of T cell receptor associated protein kinase 70

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.