PIK3R1, phosphoinositide-3-kinase regulatory subunit 1

PIK3R1, phosphoinositide-3-kinase regulatory subunit 1

• Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

• Gene Synonyms (phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PI3K regulatory subunit alpha, phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha), phosphatidylinositol 3-kinase-associated p-85 alpha, phosphoinositide-3-kinase regulatory subunit alpha, phosphoinositide-3-kinase, regulatory subunit 1 (alpha), ptdIns-3-kinase regulatory subunit alpha, AGM7, GRB1, IMD36, p85, p85-ALPHA,)
• NCBI Gene ID: 5295
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P27986
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphoinositide-3-kinase regulatory subunit 1 interacts with:

• abl interactor 1
  activator of HSP90 ATPase activity 1
  ADAM metallopeptidase domain 12
  ADAM metallopeptidase with thrombospondin type 1 motif 2
  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  Aly/REF export factor
  aminopeptidase puromycin sensitive
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
  ATPase family AAA domain containing 3A
  AT-rich interaction domain 2
  BCAR1 scaffold protein, Cas family member
  bromodomain containing 7
  catenin (cadherin associated protein), beta 1
  C-C motif chemokine ligand 14
  CD2 associated protein
  CD244 molecule
  chromatin assembly factor 1 subunit A
  clathrin heavy chain linker domain containing 1
  c-Maf inducing protein
  cullin 3
  cytokine dependent hematopoietic cell linker
  cytoskeleton associated protein 4
  DAB2 interacting protein
  enkurin, TRPC channel interacting protein
  epsin 1
  ezrin
  F-box and leucine rich repeat protein 2
  fibronectin leucine rich transmembrane protein 1
  G3BP stress granule assembly factor 2
  GRB2 associated binding protein 2
  GRB2 associated binding protein 3
  growth factor receptor bound protein 2-associated protein 2
  hematopoietic cell signal transducer
  hepatitis A virus cellular receptor 2
  hepatocyte growth factor-regulated tyrosine kinase substrate
  histone deacetylase 3
  IKAROS family zinc finger 3
  importin 7
  inducible T cell costimulator
  insulin receptor substrate 2
  insulin receptor substrate 4
  interleukin 20 receptor subunit alpha
  intersectin 1
  kelch repeat and BTB domain containing 2
  KH RNA binding domain containing, signal transduction associated 1
  KH-type splicing regulatory protein
  kinesin family member 23
  KIT proto-oncogene receptor tyrosine kinase
  leptin receptor
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat kinase 2
  ligand of numb-protein X 2
  linker for activation of T cells
  mediator complex subunit 28
  mitogen-activated protein kinase 8
  myosin XVI
  neuroligin 3
  neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1
  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
  nischarin
  NOP2/Sun RNA methyltransferase 2
  nucleolar and coiled-body phosphoprotein 1
  nucleoporin 85
  PAS domain containing serine/threonine kinase
  paxillin
  phosphatase and tensin homolog
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphoinositide-3-kinase adaptor protein 1
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 2
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 19
  pre-mRNA processing factor 8
  presenilin 1
  prominin 1
  prostaglandin E receptor 3
  proteasome 20S subunit beta 5
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 6
  protein phosphatase 2 phosphatase activator
  protein phosphatase, Mg2+/Mn2+ dependent 1A
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type K
  PTPRF interacting protein alpha 1
  PTTG1 regulator of sister chromatid separation, securin
  PX domain containing serine/threonine kinase like
  RAB5A, member RAS oncogene family
  Rac family small GTPase 1
  Rac GTPase activating protein 1
  RAS p21 protein activator 1
  RAS related 2
  RASD family member 2
  RB transcriptional corepressor 1
  receptor for activated C kinase 1
  receptor interacting serine/threonine kinase 4
  ret proto-oncogene
  retinoic acid receptor alpha
  retinoid X receptor alpha
  Rho GTPase activating protein 17
  Rho GTPase activating protein 32
  ribosomal protein S6 kinase A2
  ring finger protein 144A
  ring finger protein 19B
  selectin P ligand
  sequestosome 1
  serine and arginine rich splicing factor 1
  SH2 domain containing 2A
  SH2 domain containing adaptor protein B
  SH3 domain containing kinase binding protein 1
  SHC adaptor protein 1
  SHC adaptor protein 3
  signal transducer and activator of transcription 3
  sirtuin 1
  solute carrier family 9 member A2
  somatostatin receptor 2
  sorting nexin 32
  sorting nexin 9
  SOS Ras/Rac guanine nucleotide exchange factor 1
  spleen associated tyrosine kinase
  splicing factor proline and glutamine rich
  SRC proto-oncogene, non-receptor tyrosine kinase
  structure specific recognition protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 6
  suppressor of cytokine signaling 7
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  synapsin I
  synemin
  T cell receptor associated transmembrane adaptor 1
  target of myb1 like 1 membrane trafficking protein
  tec protein tyrosine kinase
  TEK receptor tyrosine kinase
  tensin 4
  thyroid stimulating hormone receptor
  TNF receptor superfamily member 1A
  TNFAIP3 interacting protein 1
  toll like receptor 2
  toll like receptor 3
  transforming growth factor beta 1
  transforming growth factor beta receptor 1
  transforming growth factor beta receptor 2
  trans-golgi network protein 2
  transmembrane protein 17
  transthyretin
  TUB bipartite transcription factor
  tubulin alpha 1b
  tubulin gamma 1
  TXK tyrosine kinase
  TYRO3 protein tyrosine kinase
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosine kinase 2
  tyrosine kinase with immunoglobulin like and EGF like domains 1
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin C
  ubiquitin protein ligase E3 component n-recognin 5
  UDP-glucose glycoprotein glucosyltransferase 1
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 3
  vir like m6A methyltransferase associated
  voltage dependent anion channel 2
  von Hippel-Lindau tumor suppressor
  V-set and immunoglobulin domain containing 4
  WASP actin nucleation promoting factor
  WASP family member 3
  WD repeat and HMG-box DNA binding protein 1
  WD repeat domain 26
  WEE1 G2 checkpoint kinase
  WW domain binding protein 11
  YES proto-oncogene 1, Src family tyrosine kinase
  zeta chain of T cell receptor associated protein kinase 70
  zinc finger DHHC-type palmitoyltransferase 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.