ARHGDIB, Rho GDP dissociation inhibitor beta

ARHGDIB, Rho GDP dissociation inhibitor beta

• Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

• Gene Synonyms (rho GDP-dissociation inhibitor 2, Rho GDI 2, Rho GDP dissociation inhibitor (GDI) beta, rho-GDI beta, D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2,)
• NCBI Gene ID: 397
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P52566
  UNIPROT ID#>>A0A024RAS5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho GDP dissociation inhibitor beta interacts with:

• cadherin 1
  caspase 3
  cell division cycle 42
  ezrin
  F-box and leucine rich repeat protein 5
  Rac family small GTPase 1
  Rac family small GTPase 2
  Rac family small GTPase 3
  ras homolog family member H
  small ubiquitin like modifier 4
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin fold modifier 1
  ubiquitin protein ligase E3A
  vav guanine nucleotide exchange factor 1
  zinc finger and BTB domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.