CASP3, caspase 3

CASP3, caspase 3

• The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

• Gene Synonyms (caspase-3, CASP-3, CPP-32, PARP cleavage protease, SREBP cleavage activity 1, apopain, caspase 3, apoptosis-related cysteine peptidase, caspase 3, apoptosis-related cysteine protease, cysteine protease CPP32, procaspase3, protein Yama, CPP32, CPP32B, SCA-1,)
• NCBI Gene ID: 836
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P42574
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

caspase 3 interacts with:

• acidic residue methyltransferase 1
  A-kinase anchoring protein 8
  AKT serine/threonine kinase 3
  apoptosis inducing factor mitochondria associated 1
  apoptotic chromatin condensation inducer 1
  ataxin 3
  atrophin 1
  autophagy related 4D cysteine peptidase
  B cell receptor associated protein 31
  baculoviral IAP repeat containing 6
  baculoviral IAP repeat containing 7
  BAG cochaperone 3
  BCAR1 scaffold protein, Cas family member
  beclin 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  cadherin 1
  CASP8 and FADD like apoptosis regulator
  caspase 10
  caspase 3
  caspase 4
  caspase 6
  caspase 7
  caspase 8
  caspase 9
  catenin beta 1
  cell division cycle 27
  cell division cycle 42
  COP9 signalosome subunit 6
  cortactin
  crystallin alpha B
  cyclin dependent kinase 11A
  cyclin dependent kinase 11B
  cyclin dependent kinase 2
  cyclin dependent kinase inhibitor 1A
  DCC netrin 1 receptor
  death effector domain containing
  desmoglein 3
  DNA fragmentation factor subunit alpha
  DNA topoisomerase I
  drebrin like
  dynactin subunit 1
  ELAV like RNA binding protein 1
  endoplasmic reticulum protein 44
  eukaryotic translation elongation factor 2
  eukaryotic translation initiation factor 2 alpha kinase 2
  eukaryotic translation initiation factor 2 subunit alpha
  eukaryotic translation initiation factor 3 subunit J
  eukaryotic translation initiation factor 4 gamma 2
  eukaryotic translation initiation factor 4B
  F-box and WD repeat domain containing 11
  FYN proto-oncogene, Src family tyrosine kinase
  GATA binding protein 1
  gelsolin
  geminin DNA replication inhibitor
  glutaredoxin
  golgi reassembly stacking protein 1
  golgin A3
  granzyme B
  granzyme B
  GRIP1 associated protein 1
  heat shock protein family B (small) member 1
  heat shock protein family D (Hsp60) member 1
  heat shock protein family E (Hsp10) member 1
  hematopoietic cell-specific Lyn substrate 1
  hes related family bHLH transcription factor with YRPW motif 2
  heterogeneous nuclear ribonucleoprotein U
  high mobility group box 1
  huntingtin
  huntingtin interacting protein 1
  interleukin 16
  interleukin 18
  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
  keratin 18
  lamin B1
  leucine carboxyl methyltransferase 1
  LSM family member 14B
  LYN proto-oncogene, Src family tyrosine kinase
  MCL1 apoptosis regulator, BCL2 family member
  MDM2 proto-oncogene
  MDM4 regulator of p53
  mediator of DNA damage checkpoint 1
  MET proto-oncogene, receptor tyrosine kinase
  microtubule associated protein tau
  mitogen-activated protein kinase 14
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 8 interacting protein 3
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase kinase 14
  mitogen-activated protein kinase kinase kinase kinase 1
  mutL homolog 1
  myocyte enhancer factor 2A
  myosin light chain 3
  NADH:ubiquinone oxidoreductase core subunit S1
  NEDD4 E3 ubiquitin protein ligase
  neogenin 1
  N-myristoyltransferase 2
  nuclear factor, erythroid 2 like 2
  p21 (RAC1) activated kinase 2
  paxillin
  PC4 and SFRS1 interacting protein 1
  phosphatidylinositol binding clathrin assembly protein
  phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
  phosphodiesterase 10A
  phosphodiesterase 5A
  phospholipase A2 group IVA
  phospholipase A2 group IVB
  pleckstrin homology domain containing O1
  poly(ADP-ribose) glycohydrolase
  polypyrimidine tract binding protein 1
  potassium voltage-gated channel interacting protein 3
  potassium voltage-gated channel subfamily A member 10
  presenilin 1
  presenilin 2
  prostaglandin E synthase 3
  proteasome activator subunit 3
  protein kinase C theta
  protein kinase C zeta
  protein kinase N1
  protein kinase N2
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 3 catalytic subunit alpha
  prothymosin alpha
  PTTG1 regulator of sister chromatid separation, securin
  rabaptin, RAB GTPase binding effector protein 1
  Rac family small GTPase 1
  RAD51 recombinase
  RAS p21 protein activator 1
  RB transcriptional corepressor 1
  replication factor C subunit 1
  Rho associated coiled-coil containing protein kinase 1
  ring finger protein 2
  ring-box 1
  serine/threonine kinase 24
  serine/threonine kinase 3
  serine/threonine kinase 4
  serpin family B member 8
  serum response factor
  seryl-tRNA synthetase 2, mitochondrial
  signal recognition particle 72
  signal transducer and activator of transcription 1
  small nuclear ribonucleoprotein U1 subunit 70
  solute carrier family 35 member A1
  Sp1 transcription factor
  spectrin alpha, non-erythrocytic 1
  spermatogenesis and oogenesis specific basic helix-loop-helix 1
  S-phase kinase associated protein 2
  STE20 like kinase
  sterol regulatory element binding transcription factor 2
  suppressor of cytokine signaling 5
  tensin 4
  THAP domain containing 11
  TNF receptor associated factor 1
  TNF receptor associated factor 2
  TNF receptor associated factor 3
  TNF superfamily member 10
  transcription factor AP-2 alpha
  transglutaminase 2
  tripartite motif containing 28
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  ubiquitination factor E4B
  USO1 vesicle transport factor
  vav guanine nucleotide exchange factor 1
  vimentin
  WEE1 G2 checkpoint kinase
  zinc finger and BTB domain containing 16

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.