MAP3K1, mitogen-activated protein kinase kinase kinase 1

MAP3K1, mitogen-activated protein kinase kinase kinase 1

• The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

• Gene Synonyms (MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6, mitogen-activated protein kinase kinase kinase 1, MAP/ERK kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase,)
• NCBI Gene ID: 4214
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13233
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase 1 interacts with:

• activating signal cointegrator 1 complex subunit 2
  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  apurinic/apyrimidinic endodeoxyribonuclease 2
  ataxin 3
  axin 1
  BAALC binder of MAP3K1 and KLF4
  BRCA1 associated protein 1
  caspase recruitment domain family member 14
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 85
  centrosomal protein 85
  coiled-coil domain containing 69
  COP9 signalosome subunit 6
  CREB regulated transcription coactivator 1
  CUE domain containing 1
  cysteine rich with EGF like domains 1
  DDB1 and CUL4 associated factor 7
  defective in cullin neddylation 1 domain containing 1
  defective in cullin neddylation 1 domain containing 2
  DENN domain containing 6B
  DnaJ heat shock protein family (Hsp40) member B6
  dual specificity tyrosine phosphorylation regulated kinase 1B
  epsin 1
  exportin 1
  family with sequence similarity 184 member A
  Fas associated factor family member 2
  FKBP prolyl isomerase 6
  FRAT regulator of WNT signaling pathway 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 2
  GRIP1 associated protein 1
  HBS1 like translational GTPase
  hepatocyte growth factor-regulated tyrosine kinase substrate
  homeodomain interacting protein kinase 2
  impact RWD domain protein
  inflammation and lipid regulator with UBA-like and NBR1-like domains
  keratin 36
  lysine acetyltransferase 5
  lysine demethylase 5C
  MINDY lysine 48 deubiquitinase 3
  MIS12 kinetochore complex component
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 8 interacting protein 3
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase 7
  mitogen-activated protein kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase kinase 4
  neurotrophic receptor tyrosine kinase 1
  NFKB inhibitor alpha
  NIMA related kinase 10
  NOP56 ribonucleoprotein
  notch receptor 1
  NPL4 homolog, ubiquitin recognition factor
  outer dense fiber of sperm tails 2
  p21 (RAC1) activated kinase 1
  pleckstrin homology domain containing B2
  proteasome 26S subunit, non-ATPase 4
  RAB3A interacting protein like 1
  rabaptin, RAB GTPase binding effector protein 2
  RAD18 E3 ubiquitin protein ligase
  RAD23 homolog A, nucleotide excision repair protein
  RAD51 associated protein 1
  Raf-1 proto-oncogene, serine/threonine kinase
  RANBP2-type and C3HC4-type zinc finger containing 1
  ribosomal protein L30
  ribosomal protein L4
  ribosomal protein S13
  ring finger protein 114
  ring finger protein 126
  ring finger protein 141
  serine/threonine kinase 38
  signal transducing adaptor molecule
  signal transducing adaptor molecule 2
  spartin
  target of myb1 like 2 membrane trafficking protein
  target of myb1 membrane trafficking protein
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TNF receptor associated factor 2
  TNFAIP3 interacting protein 1
  tripartite motif containing 5
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  UBA domain containing 1
  ubiquilin 1
  ubiquitin associated and SH3 domain containing B
  ubiquitin associated protein 1
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 G1
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 V1
  ubiquitin conjugating enzyme E2 W
  ubiquitin C-terminal hydrolase L5
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 28
  UBX domain protein 7
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  zinc finger AN1-type containing 3
  zinc finger AN1-type containing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.