MAP3K11, mitogen-activated protein kinase kinase kinase 11

MAP3K11, mitogen-activated protein kinase kinase kinase 11

• The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

• Gene Synonyms (MEKK11, MLK-3, MLK3, PTK1, SPRK, mitogen-activated protein kinase kinase kinase 11, SH3 domain-containing proline-rich kinase, mixed lineage kinase 3, protein-tyrosine kinase PTK1, src-homology 3 domain-containing proline-rich kinase,)
• NCBI Gene ID: 4296
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R5E6
  UNIPROT ID#>>Q16584
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase kinase kinase 11 interacts with:

• cell division cycle 37, HSP90 cochaperone
  COP9 signalosome subunit 5
  C-type lectin domain family 4 member G
  kinesin associated protein 3
  kinesin family member 17
  kinesin family member 3A
  kinesin family member 3B
  mitogen-activated protein kinase 8 interacting protein 1
  mitogen-activated protein kinase 8 interacting protein 2
  mitogen-activated protein kinase 8 interacting protein 3
  mitogen-activated protein kinase kinase 1
  mitogen-activated protein kinase kinase 4
  mitogen-activated protein kinase kinase 7
  mitogen-activated protein kinase kinase kinase 11
  mitogen-activated protein kinase kinase kinase 12
  mitogen-activated protein kinase kinase kinase 21
  mitogen-activated protein kinase kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase kinase 2
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  Rac family small GTPase 1
  SH3 domain containing ring finger 1
  STIP1 homology and U-box containing protein 1
  TNF receptor associated factor 2
  TNF receptor associated factor 6
  tripartite motif containing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.