MX1, MX dynamin like GTPase 1

MX1, MX dynamin like GTPase 1

• This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

• Gene Synonyms (IFI-78K, IFI78, MX, MxA, lncMX1-215, interferon-induced GTP-binding protein Mx1, interferon-induced protein p78, interferon-inducible protein p78, interferon-regulated resistance GTP-binding protein MxA, myxoma resistance protein 1, myxovirus (influenza virus) resistance 1, interferon-inducible protein p78,)
• NCBI Gene ID: 4599
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P20591
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MX dynamin like GTPase 1 interacts with:

• adhesion regulating molecule 1
  bromodomain containing 7
  calcium binding protein 39 like
  caspase 8 associated protein 2
  chromobox 4
  chromosome 7 open reading frame 25
  cyclic GMP-AMP synthase
  EPM2A interacting protein 1
  glucocorticoid modulatory element binding protein 1
  HMG-box containing 4
  ISG15 ubiquitin like modifier
  kelch like family member 35
  kinesin family member 26B
  leucine rich repeat containing 4B
  methylcrotonoyl-CoA carboxylase 1
  mitochondrial coiled-coil domain 1
  MX dynamin like GTPase 1
  pleckstrin and Sec7 domain containing 3
  pleiotropic regulator 1
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 2
  RELA proto-oncogene, NF-kB subunit
  siah E3 ubiquitin protein ligase 1
  signal regulatory protein alpha
  small ubiquitin like modifier 1
  solute carrier family 25 member 3
  SP100 nuclear antigen
  thymine DNA glycosylase
  transient receptor potential cation channel subfamily C member 1
  transient receptor potential cation channel subfamily C member 3
  transient receptor potential cation channel subfamily C member 4
  transient receptor potential cation channel subfamily C member 5
  transient receptor potential cation channel subfamily C member 6
  transient receptor potential cation channel subfamily C member 7
  tubulin alpha 1a
  tubulin beta class I
  ubiquitin conjugating enzyme E2 I
  zinc finger and BTB domain containing 16
  zinc finger CCHC-type containing 12
  zinc finger protein 251
  zinc finger protein 623

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.