MYCN, MYCN proto-oncogene, bHLH transcription factor

MYCN, MYCN proto-oncogene, bHLH transcription factor

• This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

• Gene Synonyms (MODED, N-myc, NMYC, ODED, bHLHe37, N-myc proto-oncogene protein, class E basic helix-loop-helix protein 37, neuroblastoma MYC oncogene, neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene, oncogene NMYC, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog,)
• NCBI Gene ID: 4613
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P04198
  UNIPROT ID#>>A0A1W2PPD9
  UNIPROT ID#>>Q9H224
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MYCN proto-oncogene, bHLH transcription factor interacts with:

• aurora kinase A
  DOT1 like histone lysine methyltransferase
  E1A binding protein p400
  F-box and WD repeat domain containing 7
  forkhead box R1
  glutaminase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 5
  histone deacetylase 9
  leucine rich pentatricopeptide repeat containing
  lysine demethylase 1A
  lysine demethylase 5B
  NEDD4 E3 ubiquitin protein ligase
  N-myc and STAT interactor
  non-POU domain containing octamer binding
  nucleolin
  ornithine decarboxylase 1
  RB transcriptional corepressor 1
  sirtuin 1
  solute carrier family 1 member 2
  Sp1 transcription factor
  S-phase kinase associated protein 2
  transformation/transcription domain associated protein
  tripartite motif containing 32
  tumor protein p73
  ubiquitin C
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 7
  WD repeat domain 5
  Y-box binding protein 1
  YEATS domain containing 4
  YY1 associated factor 2
  zinc finger and BTB domain containing 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.