NCL, nucleolin

NCL, nucleolin

• Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]

• Gene Synonyms (C23, Nsr1, nucleolin,)
• NCBI Gene ID: 4691
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KM80
  UNIPROT ID#>>P19338
  UNIPROT ID#>>A0A024R4A0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nucleolin interacts with:

• 3-oxoacid CoA-transferase 1
  AAR2 splicing factor
  acidic nuclear phosphoprotein 32 family member B
  ADP ribosylation factor guanine nucleotide exchange factor 1
  A-kinase anchoring protein 5
  Aly/REF export factor
  anaphase promoting complex subunit 1
  anaphase promoting complex subunit 7
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inhibitor 5
  ArfGAP with dual PH domains 1
  ArfGAP with dual PH domains 2
  ariadne RBR E3 ubiquitin protein ligase 2
  ATP binding cassette subfamily F member 2
  aurora kinase A
  autophagy related 16 like 1
  BAG cochaperone 3
  biogenesis of ribosomes BRX1
  bromodomain containing 7
  cap methyltransferase 1
  CCCTC-binding factor
  cell division cycle 73
  centrosomal protein 170
  chromobox 1
  chromobox 5
  chromobox 6
  chromobox 8
  chromosome 7 open reading frame 50
  coiled-coil domain containing 8
  coiled-coil-helix-coiled-coil-helix domain containing 3
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COPI coat complex subunit epsilon
  cullin 1
  cullin 2
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin dependent kinase 11A
  cytoplasmic FMR1 interacting protein 1
  DDB1 and CUL4 associated factor 1
  DDB1 and CUL4 associated factor 4 like 2
  DEAD-box helicase 18
  DEAD-box helicase 24
  DEAD-box helicase 41
  DEAD-box helicase 47
  death associated protein 3
  defective in cullin neddylation 1 domain containing 1
  DExD-box helicase 21
  DExD-box helicase 50
  DExH-box helicase 30
  DGCR8 microprocessor complex subunit
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member C17
  EBNA1 binding protein 2
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit G
  eukaryotic translation initiation factor 3 subunit L
  eukaryotic translation initiation factor 5B
  exosome component 10
  exosome component 2
  exosome component 4
  exosome component 9
  Fas associated factor 1
  F-box protein 25
  F-box protein 7
  forty-two-three domain containing 1
  FtsJ RNA 2'-O-methyltransferase 3
  G protein nucleolar 3
  GDNF inducible zinc finger protein 1
  gigaxonin
  glutamate rich WD repeat containing 1
  GTP binding protein 4
  H1.10 linker histone
  H2A clustered histone 20
  H2B clustered histone 21
  H3 clustered histone 15
  H3.4 histone
  H4 clustered histone 1
  HDGF like 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 6
  immunoglobulin superfamily member 8
  insulin like growth factor 2 mRNA binding protein 1
  integrin alpha FG-GAP repeat containing 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  Ly1 antibody reactive
  MAGE family member D2
  mannosyl-oligosaccharide glucosidase
  mediator of DNA damage checkpoint 1
  metadherin
  methylphosphate capping enzyme
  methyltransferase like 14
  mitochondrial poly(A) polymerase
  mitochondrial ribosomal protein S26
  mitochondrial ribosomal protein S34
  mitochondrial ribosomal protein S7
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase kinase 3
  MRT4 homolog, ribosome maturation factor
  Mtr4 exosome RNA helicase
  MYB binding protein 1a
  NEDD8 ubiquitin like modifier
  neurotrophic receptor tyrosine kinase 1
  N-myc downstream regulated 1
  NOP2/Sun RNA methyltransferase 2
  NOP53 ribosome biogenesis factor
  NOP56 ribonucleoprotein
  NOP9 nucleolar protein
  nuclear receptor binding SET domain protein 2
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  nucleolar complex associated 4 homolog
  nucleolin
  nucleophosmin 1
  nucleophosmin/nucleoplasmin 3
  nucleoporin 62
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase 3
  p53-induced death domain protein 1
  parkin RBR E3 ubiquitin protein ligase
  peptidylprolyl isomerase E
  pescadillo ribosomal biogenesis factor 1
  peter pan homolog
  PHD finger protein 5A
  phosphoinositide-3-kinase regulatory subunit 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(A) specific ribonuclease subunit PAN2
  poly(rC) binding protein 1
  poly(U) binding splicing factor 60
  polypyrimidine tract binding protein 1
  polyribonucleotide nucleotidyltransferase 1
  potassium channel tetramerization domain containing 10
  potassium channel tetramerization domain containing 12
  POU class 5 homeobox 1
  PPARG coactivator 1 alpha
  pre-mRNA processing factor 3
  pre-mRNA processing factor 8
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  prohibitin
  proliferation-associated 2G4
  prostaglandin-endoperoxide synthase 1
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 14
  protein arginine methyltransferase 5
  protein kinase C zeta
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 6 catalytic subunit
  protein phosphatase, Mg2+/Mn2+ dependent 1D
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type Z1
  prothymosin alpha
  PTEN induced kinase 1
  PWP1 homolog, endonuclein
  RAD18 E3 ubiquitin protein ligase
  RAD51 recombinase
  radixin
  Ran GTPase activating protein 1
  RE1 silencing transcription factor
  RecQ like helicase 4
  RecQ like helicase 5
  regulatory factor X associated protein
  replication factor C subunit 3
  replication protein A1
  replication protein A2
  replication protein A3
  reticulocalbin 1
  ribosomal L1 domain containing 1
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L13
  ribosomal protein L13a
  ribosomal protein L14
  ribosomal protein L15
  ribosomal protein L17
  ribosomal protein L18
  ribosomal protein L18a
  ribosomal protein L19
  ribosomal protein L21
  ribosomal protein L22
  ribosomal protein L23
  ribosomal protein L23a
  ribosomal protein L24
  ribosomal protein L26 like 1
  ribosomal protein L27
  ribosomal protein L27a
  ribosomal protein L28
  ribosomal protein L3
  ribosomal protein L31
  ribosomal protein L35a
  ribosomal protein L36
  ribosomal protein L37a
  ribosomal protein L4
  ribosomal protein L5
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L8
  ribosomal protein L9
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S10
  ribosomal protein S12
  ribosomal protein S13
  ribosomal protein S14
  ribosomal protein S15
  ribosomal protein S16
  ribosomal protein S17
  ribosomal protein S18
  ribosomal protein S19
  ribosomal protein S2
  ribosomal protein S20
  ribosomal protein S23
  ribosomal protein S24
  ribosomal protein S25
  ribosomal protein S26
  ribosomal protein S27
  ribosomal protein S3
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S5
  ribosomal protein S6
  ribosomal protein S6 kinase B2
  ribosomal protein S7
  ribosomal protein S8
  ribosomal protein S9
  ribosomal RNA processing 1
  ribosomal RNA processing 1 homolog B (S. cerevisiae)
  ribosomal RNA processing 1B
  ribosome biogenesis regulator 1 homolog
  ribosome production factor 2 homolog
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 146
  ring finger protein 168
  ring finger protein 2
  ring finger protein 31
  ring finger protein 4
  ring-box 1
  RIO kinase 1
  RNA binding motif protein 39
  RNA binding motif protein 42
  RNA binding motif protein 46
  RNA polymerase I and III subunit C
  RNA polymerase I subunit G
  RNA polymerase II subunit B
  RNA terminal phosphate cyclase like 1
  S100 calcium binding protein A11
  septin 9
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 5
  signal recognition particle 14
  signal recognition particle 72
  sirtuin 7
  SKI proto-oncogene
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein polypeptide N
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U5 subunit 200
  small RNA binding exonuclease protection factor La
  snail family transcriptional repressor 1
  solute carrier family 25 member 1
  Sp1 transcription factor
  spartin
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3b subunit 4
  splicing regulatory glutamic acid and lysine rich protein 1
  SPT4 homolog, DSIF elongation factor subunit
  SPT5 homolog, DSIF elongation factor subunit
  SPT6 homolog, histone chaperone and transcription elongation factor
  SRSF protein kinase 1
  SRSF protein kinase 2
  SRSF protein kinase 3
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 2
  structural maintenance of chromosomes 3
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  switching B cell complex subunit SWAP70
  TAR DNA binding protein
  TATA-box binding protein associated factor 4
  telomerase reverse transcriptase
  telomeric repeat binding factor 2
  thymopoietin
  TNFAIP3 interacting protein 2
  TRAF interacting protein
  transcription factor CP2
  transformed mouse 3T3 cell double minute 2
  translocase of outer mitochondrial membrane 40
  transmembrane protein 41B
  tripartite motif containing 25
  TSR1 ribosome maturation factor
  tumor necrosis factor
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 S
  ubiquitin like 4A
  ubiquitin specific peptidase 39
  ubiquitin specific peptidase 7
  unk zinc finger
  vascular cell adhesion molecule 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  von Hippel-Lindau tumor suppressor
  VRK serine/threonine kinase 1
  VRK serine/threonine kinase 3
  WD repeat domain 43
  WD repeat domain 46
  WD repeat domain 77
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 5
  Y-box binding protein 1
  Yes1 associated transcriptional regulator
  YY1 transcription factor
  ZFP36 ring finger protein
  ZFP41 zinc finger protein
  zinc finger and BTB domain containing 1
  zinc finger CCCH-type containing 15
  zinc finger CCCH-type containing, antiviral 1
  zinc finger protein 689
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.