NACA, nascent polypeptide associated complex subunit alpha

NACA, nascent polypeptide associated complex subunit alpha

• This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]

• Gene Synonyms (HSD48, NAC-alpha, NACA1, skNAC, nascent polypeptide-associated complex subunit alpha, alpha-NAC, muscle-specific form, nascent-polypeptide-associated complex alpha polypeptide,)
• NCBI Gene ID: 4666
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13765
  UNIPROT ID#>>A0A024RB41
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nascent polypeptide associated complex subunit alpha interacts with:

• basic transcription factor 3 like 4
  bromodomain containing 7
  casein kinase 1, epsilon
  cell division cycle 37, HSP90 cochaperone
  coiled-coil domain containing 15
  coiled-coil domain containing 8
  coiled-coil domain containing 90B
  cullin 3
  developmental pluripotency associated 4
  dynamin 1 like
  elongation factor Tu GTP binding domain containing 2
  expressed sequence AI837181
  family with sequence similarity 50 member A
  Fas associated factor 1
  Fas associated via death domain
  F-box and leucine rich repeat protein 13
  F-box and WD repeat domain containing 11
  FUN14 domain containing 2
  glutamate rich WD repeat containing 1
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  H3 clustered histone 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  immunoglobin superfamily member 21
  integrin alpha FG-GAP repeat containing 1
  ISG15 ubiquitin like modifier
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  ligand dependent nuclear receptor interacting factor 1
  mab-21 like 2
  methyltransferase like 14
  nascent polypeptide associated complex subunit alpha 2
  nestin
  neurotrophic receptor tyrosine kinase 1
  nuclear protein 1, transcriptional regulator
  nuclear receptor subfamily 2 group C member 2
  parkin RBR E3 ubiquitin protein ligase
  PDS5 cohesin associated factor A
  phosphoinositide-3-kinase regulatory subunit 1
  pleckstrin homology domain containing A4
  polo like kinase 4
  polysaccharide biosynthesis domain containing 1
  pre-mRNA processing factor 8
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 regulatory subunit 18
  protein phosphatase 1 regulatory subunit 9B
  protein phosphatase 2 scaffold subunit Aalpha
  PTEN induced kinase 1
  pyruvate carboxylase
  RAD21 cohesin complex component
  regulatory associated protein of MTOR complex 1
  ribosomal protein L10
  ribosomal protein L24
  ring finger and CCCH-type domains 2
  secreted phosphoprotein 1
  SET and MYND domain containing 1
  Shoc2, leucine rich repeat scaffold protein
  sperm antigen with calponin homology and coiled-coil domains 1 like
  SUB1 regulator of transcription
  superoxide dismutase 1
  supervillin
  TAR DNA binding protein
  TATA-box binding protein
  taxilin alpha
  ubiquilin 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin specific peptidase 14
  vir like m6A methyltransferase associated
  WW domain containing E3 ubiquitin protein ligase 2
  zinc finger HIT-type containing 6
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.