PLK1, polo like kinase 1

PLK1, polo like kinase 1

• The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]

• Gene Synonyms (serine/threonine-protein kinase PLK1, PLK-1, cell cycle regulated protein kinase, polo (Drosophia)-like kinase, serine/threonine-protein kinase 13, PLK, STPK13,)
• NCBI Gene ID: 5347
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P53350
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

polo like kinase 1 interacts with:

• 5-hydroxymethylcytosine binding, ES cell specific
  actin like 6B
  activator of HSP90 ATPase activity 1
  adaptor related protein complex 4 subunit mu 1
  adenosylhomocysteinase like 1
  anaphase promoting complex subunit 1
  anaphase promoting complex subunit 2
  anaphase promoting complex subunit 7
  ankyrin repeat domain 28
  ankyrin repeat domain 44
  ankyrin repeat domain 52
  aspartate rich 1
  assembly factor for spindle microtubules
  ATP/GTP binding protein 1
  aurora kinase A
  baculoviral IAP repeat containing 6
  BAG cochaperone 6
  BICD cargo adaptor 2
  BORA aurora kinase A activator
  BRISC and BRCA1 A complex member 1
  calcium voltage-gated channel auxiliary subunit gamma 3
  calmodulin like 5
  capicua transcriptional repressor
  caspase recruitment domain family member 14
  cell division cycle 14A
  cell division cycle 16
  cell division cycle 20B
  cell division cycle associated 5
  centriolin
  centrobin, centriole duplication and spindle assembly protein
  centromere protein J
  centromere protein Q
  centromere protein U
  centrosomal protein 104
  centrosomal protein 128
  centrosomal protein 135
  centrosomal protein 162
  centrosomal protein 43
  centrosomal protein 55
  centrosomal protein 97
  checkpoint kinase 2
  checkpoint with forkhead and ring finger domains
  chromodomain helicase DNA binding protein 1 like
  chromosome 1 open reading frame 226
  chromosome 6 open reading frame 136
  cilia and flagella associated protein 20
  claspin
  coiled-coil domain containing 115
  coiled-coil domain containing 6
  COP9 signalosome subunit 5
  cullin 2
  cullin 4A
  cullin 7
  dCTP pyrophosphatase 1
  DDB1 and CUL4 associated factor 1
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 7
  DEAD-box helicase 17
  debranching RNA lariats 1
  dicer 1, ribonuclease III
  DNA topoisomerase II alpha
  DNA topoisomerase II binding protein 1
  dynein axonemal assembly factor 5
  dynein heavy chain domain 1
  ecotropic viral integration site 5
  egl-9 family hypoxia inducible factor 3
  embryonic ectoderm development
  endosome associated trafficking regulator 1
  epidermal growth factor receptor pathway substrate 15 like 1
  ERCC excision repair 6 like, spindle assembly checkpoint helicase
  excision repair cross-complementing rodent repair deficiency complementation group 6 like
  family with sequence similarity 131 member B
  family with sequence similarity 53 member C
  Fas binding factor 1
  fasciculation and elongation protein zeta 1
  F-box and leucine rich repeat protein 5
  F-box and WD repeat domain containing 7
  F-box protein 5
  F-box protein 6
  FERM, ARH/RhoGEF and pleckstrin domain protein 2
  fizzy and cell division cycle 20 related 1
  G protein-coupled receptor associated sorting protein 2
  general transcription factor IIIC subunit 3
  general transcription factor IIIC subunit 4
  general transcription factor IIIC subunit 5
  golgi reassembly stacking protein 1
  GTPase activating protein and VPS9 domains 1
  guided entry of tail-anchored proteins factor 4
  HAUS augmin-like complex, subunit 3
  HAUS augmin-like complex, subunit 4
  influenza virus NS1A binding protein
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  insulin receptor substrate 2
  integrator complex subunit 11
  intersectin 1
  intraflagellar transport 43
  intraflagellar transport associated protein
  jade family PHD finger 1
  kelch like family member 21
  kelch like family member 22
  kelch like family member 9
  kinesin family member 23
  kinesin family member 2C
  kinetochore localized astrin (SPAG5) binding protein
  KRAB-A domain containing 1
  Kruppel like factor 4
  large tumor suppressor kinase 1
  LDL receptor related protein 5 like
  lebercilin LCA5
  leucine rich repeat kinase 1
  leucine rich repeat kinase 2
  LIM domain only 4
  lysine acetyltransferase 8
  MAD2L1 binding protein
  MAGE family member D1
  MAPK activated protein kinase 2
  mediator complex subunit 1
  membrane anchored junction protein
  microtubule associated serine/threonine kinase like
  MIER family member 2
  mindbomb E3 ubiquitin protein ligase 1
  mitochondrial antiviral signaling protein
  mitochondrial ribosomal protein L55
  mitogen-activated protein kinase 6
  MUS81 structure-specific endonuclease subunit
  myosin phosphatase Rho interacting protein
  myotubularin related protein 14
  myotubularin related protein 3
  myotubularin related protein 4
  NDC80 kinetochore complex component
  NEDD1 gamma-tubulin ring complex targeting factor
  NHS like 2
  NIMA related kinase 7
  ninein
  ninein like
  nitric oxide synthase 1 adaptor protein
  NME/NM23 family member 7
  NUAK family kinase 1
  nuclear distribution C, dynein complex regulator
  nuclear receptor subfamily 2 group C member 2
  OFD1 centriole and centriolar satellite protein
  Opa interacting protein 5
  origin recognition complex subunit 3
  oxysterol binding protein like 6
  p21 (RAC1) activated kinase 5
  parathyroid hormone like hormone
  PAS domain containing serine/threonine kinase
  peptidylprolyl isomerase D
  phosphatase and tensin homolog
  phosphatidylinositol transfer protein membrane associated 1
  pleckstrin homology domain containing A4
  polo like kinase 1
  polo like kinase 4
  proline rich coiled-coil 1
  proteasome 20S subunit alpha 1
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 3
  proteasome 20S subunit alpha 4
  proteasome 20S subunit alpha 5
  proteasome 20S subunit alpha 6
  proteasome 20S subunit alpha 7
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  protein kinase cAMP-dependent type I regulatory subunit alpha
  protein kinase, membrane associated tyrosine/threonine 1
  protein phosphatase 2 regulatory subunit Bdelta
  protein phosphatase 2 regulatory subunit B'delta
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 6 catalytic subunit
  protein phosphatase 6 regulatory subunit 1
  protein phosphatase 6 regulatory subunit 2
  protein phosphatase 6 regulatory subunit 3
  protein regulator of cytokinesis 1
  protein tyrosine phosphatase non-receptor type 14
  protein tyrosine phosphatase receptor type D
  Rab acceptor 1
  RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
  Rac GTPase activating protein 1
  RAD51 recombinase
  RANBP2 like and GRIP domain containing 4
  RAP1 GTPase activating protein
  RB binding protein 8, endonuclease
  RE1 silencing transcription factor
  RecQ like helicase 4
  RecQ like helicase 5
  regulator of cell cycle
  regulator of G protein signaling 20
  regulatory factor X3
  RELA proto-oncogene, NF-kB subunit
  retinoic acid induced 14
  retinoid X receptor alpha
  Rho/Rac guanine nucleotide exchange factor 2
  ribonuclease P/MRP subunit p25 like
  ribonucleic acid export 1
  ribonucleotide reductase regulatory subunit M2
  ribonucleotide reductase regulatory TP53 inducible subunit M2B
  ribosomal protein L3
  ring finger protein 126
  ring finger protein 2
  RPTOR independent companion of MTOR complex 2
  sacsin molecular chaperone
  SATB homeobox 2
  Scm polycomb group protein like 1
  serine/threonine kinase 26
  serine/threonine kinase 3
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
  shugoshin 1
  SLX1 homolog B, structure-specific endonuclease subunit
  SLX4 interacting protein
  SLX4 structure-specific endonuclease subunit
  SNW domain containing 1
  sorcin
  sperm associated antigen 5
  sperm associated antigen 9
  spermatogenesis associated 18
  spermatogenesis associated 5
  spermatogenesis associated 5 like 1
  splicing factor 3b subunit 3
  SPOUT domain containing methyltransferase 1
  sterol regulatory element binding transcription factor 1
  STIP1 homology and U-box containing protein 1
  stromal antigen 2
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 3
  SUMO interacting motifs containing 1
  sushi repeat containing protein X-linked
  syntaxin binding protein 4
  synuclein alpha
  synuclein beta
  TANK binding kinase 1
  TARBP2 subunit of RISC loading complex
  TATA element modulatory factor 1
  TBC1 domain family member 9
  tensin 2
  terminal uridylyl transferase 7
  TNF superfamily member 11
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TRAF family member associated NFKB activator
  trafficking kinesin protein 2
  transcription factor 25
  transformed mouse 3T3 cell double minute 2
  TRIO and F-actin binding protein
  tripartite motif containing 25
  tripartite motif containing 28
  TSC complex subunit 1
  TSC complex subunit 2
  tubulin alpha 1a
  tubulin alpha 4a
  tubulin beta 3 class III
  tubulin beta class I
  tubulin gamma 1
  tumor protein p53
  tumor protein p53 binding protein 1
  tumor protein p53 binding protein 2
  tumor protein p53 inducible protein 3
  tumor protein p73
  tumor protein, translationally-controlled 1
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 13
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 16
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 37
  valosin containing protein
  vesicle associated membrane protein 4
  VRK serine/threonine kinase 3
  WAPL cohesin release factor
  WD repeat and coiled coil containing
  WEE1 G2 checkpoint kinase
  zinc finger and BTB domain containing 1
  zinc finger C3HC-type containing 1
  zinc finger CCCH-type containing 7A
  zinc finger protein 71
  zinc finger SWIM-type containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.