PKN1, protein kinase N1

PKN1, protein kinase N1

• The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

• Gene Synonyms (serine/threonine-protein kinase N1, protease-activated kinase 1, protein kinase C-like 1, protein kinase C-like PKN, protein kinase C-related kinase 1, protein kinase PKN-alpha, serine-threonine kinase N, serine/threonine protein kinase N, DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1,)
• NCBI Gene ID: 5585
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16512
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein kinase N1 interacts with:

• ADAMTS like 4
  A-kinase anchoring protein 9
  apoptosis enhancing nuclease
  ASH2 like, histone lysine methyltransferase complex subunit
  basic leucine zipper nuclear factor 1
  BUD23 rRNA methyltransferase and ribosome maturation factor
  centrosomal protein 57
  centrosomal protein 57 like 1
  centrosomal protein 70
  coiled-coil domain containing 103
  coiled-coil domain containing 136
  coiled-coil domain containing 138
  coiled-coil domain containing 85B
  component of oligomeric golgi complex 6
  cysteine rich tail 1
  DISC1 scaffold protein
  DPY30 domain containing 1
  eukaryotic translation initiation factor 3 subunit F
  fucose mutarotase
  golgin A6 family like 9
  H3 clustered histone 14
  HAUS augmin like complex subunit 1
  heat shock transcription factor 2 binding protein
  histone deacetylase 5
  homer scaffold protein 3
  huntingtin associated protein 1
  integrator complex subunit 11
  kelch repeat and BTB domain containing 8
  keratin 36
  keratin 37
  KIAA1328
  leucine rich repeat containing 61
  makorin ring finger protein 3
  metadherin
  microtubule associated scaffold protein 2
  midline 2
  mirror-image polydactyly 1
  mitogen-activated protein kinase 11
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase 6
  pleckstrin homology domain containing A4
  PNMA family member 1
  POU class 6 homeobox 2
  proteasome 20S subunit beta 4
  protein interacting with PRKCA 1
  protein kinase N1
  RAB3A interacting protein
  RB binding protein 5, histone lysine methyltransferase complex subunit
  regulator of hemoglobinization and erythroid cell expansion
  Rho GTPase activating protein 10
  Rho GTPase activating protein 26
  SERTA domain containing 3
  SET and MYND domain containing 3
  small proline rich protein 2D
  sperm associated antigen 5
  SSX family member 2 interacting protein
  synaptonemal complex central element protein 3
  syntaxin 11
  target of myb1 like 1 membrane trafficking protein
  testis specific 10
  TNF receptor associated factor 1
  TNF receptor associated factor 2
  TNF receptor superfamily member 1B
  tripartite motif containing 27
  tubulin alpha 1a
  tubulin beta class I
  ubiquitin protein ligase E3 component n-recognin 2
  USH1 protein network component harmonin binding protein 1
  vimentin
  WD repeat domain 5
  zinc finger AN1-type containing 6
  zinc finger protein 282
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.