PRPS1, phosphoribosyl pyrophosphate synthetase 1

PRPS1, phosphoribosyl pyrophosphate synthetase 1

• This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

• Gene Synonyms (ribose-phosphate pyrophosphokinase 1, dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1), deafness 2, perceptive, congenital, deafness, X-linked 2, perceptive, congenital, phosphoribosyl pyrophosphate synthase I, ribose-phosphate diphosphokinase 1, ARTS, CMTX5, DFN2, DFNX1, PPRibP, PRS-I, PRSI,)
• NCBI Gene ID: 5631
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P60891
  UNIPROT ID#>>B7ZB02
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphoribosyl pyrophosphate synthetase 1 interacts with:

• AAR2 splicing factor
  ankyrin repeat and SOCS box containing 11
  ankyrin repeat and SOCS box containing 18
  anterior gradient 2, protein disulphide isomerase family member
  armadillo repeat containing 8
  autophagy related 16 like 1
  biorientation of chromosomes in cell division 1 like 1
  BRMS1 transcriptional repressor and anoikis regulator
  CDK5 regulatory subunit associated protein 2
  cereblon
  CXXC finger protein 1
  DNA topoisomerase I mitochondrial
  DnaJ heat shock protein family (Hsp40) member A4
  dual specificity phosphatase 28
  elongation factor Tu GTP binding domain containing 2
  elongator acetyltransferase complex subunit 3
  EMAP like 4
  F-box protein 31
  F-box protein 6
  golgi reassembly stacking protein 2
  integrin alpha FG-GAP repeat containing 1
  kelch like family member 13
  myotubularin related protein 4
  NMD3 ribosome export adaptor
  N-myristoyltransferase 2
  nuclear receptor subfamily 2 group C member 2
  phosphoribosyl pyrophosphate synthetase 1
  phosphoribosyl pyrophosphate synthetase 1 like 1
  phosphoribosyl pyrophosphate synthetase 2
  phosphoribosyl pyrophosphate synthetase associated protein 1
  phosphoribosyl pyrophosphate synthetase associated protein 2
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  POC5 centriolar protein
  pre-mRNA processing factor 19
  protein tyrosine phosphatase domain containing 1
  RecQ like helicase 4
  RELA proto-oncogene, NF-kB subunit
  ribosomal protein S4 Y-linked 1
  ring finger protein 31
  RNA polymerase II associated protein 3
  SBDS ribosome maturation factor
  SET domain containing 1A, histone lysine methyltransferase
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein U1 subunit 70
  small ubiquitin like modifier 4
  snail family transcriptional repressor 1
  SPG21 abhydrolase domain containing, maspardin
  STIL centriolar assembly protein
  tectonic family member 1
  TP53 regulating kinase
  tubulin alpha 4a
  twinfilin actin binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquitin B
  UFM1 specific ligase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.