PTPRR, protein tyrosine phosphatase receptor type R

PTPRR, protein tyrosine phosphatase receptor type R

• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

• Gene Synonyms (receptor-type tyrosine-protein phosphatase R, Ch-1 PTPase, NC-PTPCOM1, R-PTP-R, ch-1PTPase, protein tyrosine phosphatase Cr1PTPase, protein-tyrosine phosphatase NC-PTPCOM1, protein-tyrosine phosphatase PCPTP1, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ,)
• NCBI Gene ID: 5801
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15256
  UNIPROT ID#>>Q7Z2V8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein tyrosine phosphatase receptor type R interacts with:

• aldehyde dehydrogenase 18 family member A1
  apoptosis associated tyrosine kinase
  centrosomal protein 290
  DnaJ heat shock protein family (Hsp40) member C13
  GABA type A receptor associated protein like 1
  heat shock protein family A (Hsp70) member 4 like
  lemur tyrosine kinase 2
  listerin E3 ubiquitin protein ligase 1
  MAD2L1 binding protein
  MAPK activated protein kinase 3
  mitogen-activated protein kinase 1 interacting protein 1 like
  PNMA family member 2
  protein only RNase P catalytic subunit
  protein tyrosine phosphatase receptor type R
  RAD23 homolog B, nucleotide excision repair protein
  receptor like tyrosine kinase
  ret proto-oncogene
  sorting nexin 6
  STIP1 homology and U-box containing protein 1
  TBC1 domain family member 5
  TEK receptor tyrosine kinase
  tripartite motif containing 11
  WASH complex subunit 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.