SET, SET nuclear proto-oncogene

SET, SET nuclear proto-oncogene

• The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Gene Synonyms (protein SET, HLA-DR-associated protein II, SET nuclear oncogene, SET translocation (myeloid leukemia-associated), Template-Activating Factor-I, chromatin remodelling factor, chromatin remodelling factor, inhibitor of granzyme A-activated DNase, inhibitor-2 of protein phosphatase-2A, phosphatase 2A inhibitor I2PP2A, protein phosphatase type 2A inhibitor, 2PP2A, I2PP2A, IGAAD, IPP2A2, MRD58, PHAPII, TAF-I, TAF-IBETA,)
• NCBI Gene ID: 6418
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5VXV3
  UNIPROT ID#>>A0A0C4DFV9
  UNIPROT ID#>>Q01105
  UNIPROT ID#>>A0A024R895
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SET nuclear proto-oncogene interacts with:

• AAR2 splicing factor
  acidic nuclear phosphoprotein 32 family member A
  ArfGAP with SH3 domain, ankyrin repeat and PH domain1
  BAF nuclear assembly factor 1
  BCL2 binding component 3
  CCCTC-binding factor
  cell division cycle associated 8
  centrosomal protein 55
  chromatin assembly factor 1 subunit A
  chromosome 11 open reading frame 58
  coenzyme Q2, polyprenyltransferase
  coiled-coil domain containing 15
  cyclin dependent kinase 5 regulatory subunit 1
  cytoskeleton associated protein 5
  diacylglycerol kinase epsilon
  elongation factor Tu GTP binding domain containing 2
  exportin 1
  expressed sequence AI837181
  family with sequence similarity 111 member B
  Fas associated factor 1
  F-box and leucine-rich repeat protein 16
  F-box protein 7
  forty-two-three domain containing 1
  FtsJ RNA 2'-O-methyltransferase 3
  glutaminase 2
  H2B clustered histone 1
  H3 clustered histone 1
  H3 clustered histone 15
  H3.4 histone
  H4 clustered histone 14
  H4 histone 16
  heat shock protein family A (Hsp70) member 14
  heat shock protein family H (Hsp110) member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  HIRA interacting protein 3
  immunoglobulin superfamily member 8
  integrin alpha FG-GAP repeat containing 1
  kinase suppressor of ras 1
  La ribonucleoprotein 7, transcriptional regulator
  lysine demethylase 5C
  macroH2A.1 histone
  matrin 3
  methylphosphate capping enzyme
  methyltransferase like 14
  midasin AAA ATPase 1
  mitochondrial transcription termination factor 1
  neural precursor cell expressed, developmentally down-regulated gene 1
  nuclear protein 1, transcriptional regulator
  OTU deubiquitinase 5
  PDS5 cohesin associated factor A
  phenylalanyl-tRNA synthetase subunit beta
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  PIH1 domain containing 1
  polo like kinase 4
  potassium channel tetramerization domain containing 12
  protein phosphatase 2, regulatory subunit A, alpha
  RAD18 E3 ubiquitin protein ligase
  RAN binding protein 3
  RecQ like helicase 4
  regulator of G protein signaling 20
  replication initiator 1
  SET binding protein 1
  SET nuclear proto-oncogene
  shugoshin 1
  shugoshin 1
  shugoshin 2
  shugoshin 2A
  spermatogenesis associated serine rich 2 like
  SPT5 homolog, DSIF elongation factor subunit
  SRY-box transcription factor 2
  sterol O-acyltransferase 1
  SUB1 regulator of transcription
  SUZ12 polycomb repressive complex 2 subunit
  switching B cell complex subunit SWAP70
  TATA-box binding protein associated factor, RNA polymerase I subunit A
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  TERF2 interacting protein
  testis expressed 35
  THAP domain containing 7
  three prime repair exonuclease 1
  threonyl-tRNA synthetase 1
  TNFAIP3 interacting protein 1
  TNFAIP3 interacting protein 2
  TP53 induced glycolysis regulatory phosphatase
  tripartite motif containing 28
  TSPY like 2
  tumor protein p53
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin specific peptidase 17 like family member 2
  ubiquitin specific peptidase 46
  UDP-glucose pyrophosphorylase 2
  vacuolar protein sorting 72 homolog
  vir like m6A methyltransferase associated
  WD repeat domain 48
  zinc finger DBF-type containing 2
  zinc finger protein 17
  zinc finger protein 438
  zinc finger protein 85

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.