TAF11, TATA-box binding protein associated factor 11

TAF11, TATA-box binding protein associated factor 11

• Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

• Gene Synonyms (transcription initiation factor TFIID subunit 11, TAF(II)28, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa, TAFII-28, TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kD, TFIID subunit p30-beta, transcription initiation factor TFIID 28 kD subunit, transcription initiation factor TFIID 28 kDa subunit, MGC:15243, PRO2134, TAF2I, TAFII28,)
• NCBI Gene ID: 6882
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15544
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TATA-box binding protein associated factor 11 interacts with:

• amyloid beta precursor protein binding protein 2
  cleavage and polyadenylation specific factor 1
  cullin 3
  H3.4 histone
  leucine zipper like transcription regulator 1
  mediator complex subunit 26
  metaxin 1
  NDC80 kinetochore complex component
  protein kinase, AMP-activated, alpha 1 catalytic subunit
  RAB4B, member RAS oncogene family
  SLAIN motif family, member 1
  TATA-box binding protein
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 12
  TATA-box binding protein associated factor 13
  TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 3
  TATA-box binding protein associated factor 7 like
  TATA-box binding protein associated factor 8
  TATA-box binding protein associated factor 9b
  thyroid hormone receptor alpha
  translin associated factor X
  tripartite motif containing 24
  UFM1 specific ligase 1
  vitamin D receptor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.