CLK1, CDC like kinase 1

CLK1, CDC like kinase 1

• This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

• Gene Synonyms (dual specificity protein kinase CLK1, CDC28/CDC2-like kinase, protein tyrosine kinase STY, CLK, CLK/STY, STY,)
• NCBI Gene ID: 1195
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49759
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

CDC like kinase 1 interacts with:

• actin related protein 2/3 complex subunit 4
  acyl-CoA oxidase 2
  A-kinase anchoring protein 5
  ankyrin repeat and FYVE domain containing 1
  ASXL transcriptional regulator 3
  ATP binding cassette subfamily A member 13
  ATPase phospholipid transporting 10A (putative)
  BAG cochaperone 3
  BCL2 associated transcription factor 1
  cadherin EGF LAG seven-pass G-type receptor 3
  cadherin related 23
  catenin delta 2
  CDC like kinase 1
  CDC like kinase 2
  centrosomal protein 95
  CFAP20 domain containing
  chromosome 1 open reading frame 94
  cilia and flagella associated protein 251
  CLK4 associating serine/arginine rich protein
  cochlin
  crooked neck pre-mRNA splicing factor 1
  CUB domain containing protein 1
  cullin 3
  cullin 9
  CWC27 spliceosome associated cyclophilin
  cyclin dependent kinase 12
  cytochrome P450 family 46 subfamily A member 1
  cytoskeleton associated protein 5
  debranching RNA lariats 1
  DENN domain containing 4A
  desmocollin 2
  dihydropyrimidine dehydrogenase
  dishevelled segment polarity protein 3
  DnaJ heat shock protein family (Hsp40) member C13
  DnaJ heat shock protein family (Hsp40) member C24
  elongator acetyltransferase complex subunit 6
  endothelin converting enzyme 1
  enolase 1
  erythroferrone
  family with sequence similarity 160 member B2
  family with sequence similarity 189 member A1
  Fas binding factor 1
  FAT atypical cadherin 1
  gasdermin B
  gem nuclear organelle associated protein 5
  glutamate metabotropic receptor 6
  golgi membrane protein 1
  H2B clustered histone 12
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein A3
  histamine N-methyltransferase
  HIV-1 Tat specific factor 1
  HIVEP zinc finger 1
  HSPA (Hsp70) binding protein 1
  hydroxyacyl-CoA dehydrogenase
  inosine monophosphate dehydrogenase 2
  inositol hexakisphosphate kinase 1
  insulin receptor
  integrin subunit alpha 5
  interactor of little elongation complex ELL subunit 1
  ISG15 ubiquitin like modifier
  katanin catalytic subunit A1
  keratin 8
  keratin associated protein 10-6
  keratin associated protein 10-7
  KH RNA binding domain containing, signal transduction associated 1
  kinesin family member 14
  kinesin family member 1B
  kinesin family member 23
  kinesin light chain 1
  lamin A/C
  ligand of numb-protein X 1
  lines homolog 1
  LUC7 like 3 pre-mRNA splicing factor
  major facilitator superfamily domain containing 10
  makorin ring finger protein 2
  malignant fibrous histiocytoma amplified sequence 1
  MDM2 binding protein
  microtubule associated protein 7
  microtubule crosslinking factor 1
  mitochondrial calcium uptake family member 3
  mitogen-activated protein kinase kinase kinase 21
  myelin basic protein
  myomesin 1
  neurofibromin 1
  nuclear receptor corepressor 1
  nucleolin
  nucleophosmin 1
  nucleoporin 153
  peptidylprolyl isomerase G
  periphilin 1
  peroxiredoxin 5
  PHD finger protein 3
  phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  phosphodiesterase 9A
  phospholipase A and acyltransferase 5
  pleckstrin homology like domain family B member 2
  plexin domain containing 2
  polycystin 1 like 1, transient receptor potential channel interacting
  POZ/BTB and AT hook containing zinc finger 1
  PPFIA binding protein 2
  pre-mRNA processing factor 38A
  pre-mRNA processing factor 4
  pre-mRNA processing factor 4B
  presenilin 2
  protein arginine methyltransferase 5
  protein inhibitor of activated STAT 4
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 4 regulatory subunit 3A
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 22
  RAB11 family interacting protein 1 (class I)
  RAD21 cohesin complex component like 1
  Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
  RAS like family 12
  RB binding protein 6, ubiquitin ligase
  REV1 DNA directed polymerase
  Rho guanine nucleotide exchange factor 12
  ribosomal protein L5
  ribosomal protein S4 Y-linked 1
  ring finger protein 4
  RLF zinc finger
  RNA binding motif protein 15
  RNA binding motif protein 39
  RNA binding motif protein X-linked
  RNA pseudouridine synthase D3
  scaffold attachment factor B
  scavenger receptor class A member 3
  schlafen family member 5
  Scm like with four mbt domains 2
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 10
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 5
  serine and arginine rich splicing factor 6
  serine and arginine rich splicing factor 7
  serine/arginine repetitive matrix 2
  serine/arginine repetitive matrix 4
  serine/threonine kinase 31
  serpin family I member 2
  SH2B adaptor protein 2
  shroom family member 1
  single stranded DNA binding protein 3
  solute carrier family 35 member D3
  spectrin beta, non-erythrocytic 4
  spen family transcriptional repressor
  splicing factor 3b subunit 1
  SRSF protein kinase 1
  SRSF protein kinase 2
  sterile alpha motif domain containing 9 like
  stress induced phosphoprotein 1
  SV2 related protein
  symplekin
  talin 2
  testis expressed 11
  Thy-1 cell surface antigen
  thymopoietin
  thyroid hormone receptor associated protein 3
  tight junction protein 2
  TNFAIP3 interacting protein 2
  TP53 regulating kinase
  transformer 2 alpha homolog
  transformer 2 beta homolog
  transmembrane serine protease 2
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  ubiquitin like 5
  unc-13 homolog B
  von Willebrand factor A domain containing 7
  YTH domain containing 1
  zinc finger CCCH-type containing 13
  zinc finger CCCH-type containing 18
  zinc finger MYND-type containing 10
  zinc finger protein 148

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.