CHUK, component of inhibitor of nuclear factor kappa B kinase complex

CHUK, component of inhibitor of nuclear factor kappa B kinase complex

• This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]

• Gene Synonyms (inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase 1, I-kappa-B kinase-alpha, IKK-a kinase, IkB kinase alpha subunit, Nuclear factor NFkappaB inhibitor kinase alpha, TCF-16, conserved helix-loop-helix ubiquitous kinase, transcription factor 16, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16,)
• NCBI Gene ID: 1147
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15111
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

component of inhibitor of nuclear factor kappa B kinase complex interacts with:

• aurora kinase A
  autophagy and beclin 1 regulator 1
  autophagy related 16 like 2
  BCL10 immune signaling adaptor
  BCL2 binding component 3
  beta-transducin repeat containing E3 ubiquitin protein ligase
  casein kinase 2 alpha 1
  caspase recruitment domain family member 11
  catenin beta 1
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  clusterin
  colony stimulating factor 2 receptor subunit alpha
  COMM domain containing 7
  component of inhibitor of nuclear factor kappa B kinase complex
  COP9 signalosome subunit 3
  COP9 signalosome subunit 5
  CREB binding protein
  CUE domain containing 2
  cullin 1
  C-X-C motif chemokine ligand 8
  DEAH-box helicase 40
  defective in cullin neddylation 1 domain containing 5
  DExH-box helicase 29
  dual specificity phosphatase 1
  E1A binding protein p300
  E2F transcription factor 4
  egl-9 family hypoxia inducible factor 3
  ELAV like RNA binding protein 1
  ELKS/RAB6-interacting/CAST family member 1
  elongator complex protein 1
  erbb2 interacting protein
  estrogen receptor 1
  estrogen receptor binding site associated antigen 9
  eukaryotic translation initiation factor 2 alpha kinase 2
  exportin 1
  FA complementation group A
  Fas associated via death domain
  FKBP prolyl isomerase 5
  forkhead box O3
  GLI family zinc finger 1
  H3 clustered histone 14
  H3.4 histone
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family B (small) member 1
  heterogeneous nuclear ribonucleoprotein A1
  huntingtin
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit beta
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  inhibitory synaptic factor 2A
  insulin receptor substrate 1
  interferon induced protein with tetratricopeptide repeats 5
  interferon regulatory factor 5
  interleukin 1 receptor associated kinase 1
  kelch like ECH associated protein 1
  kelch like family member 21
  leucine rich repeat containing 14
  MAGE family member D1
  mechanistic target of rapamycin kinase
  mitogen-activated protein kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase 11
  mitogen-activated protein kinase kinase kinase 14
  mitogen-activated protein kinase kinase kinase 3
  mitogen-activated protein kinase kinase kinase 4
  mitogen-activated protein kinase kinase kinase 7
  mitogen-activated protein kinase kinase kinase 8
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 14
  myosin light chain 12A
  neurotrophic receptor tyrosine kinase 1
  NFKB inhibitor alpha
  NFKB inhibitor beta
  NLR family CARD domain containing 5
  NLR family pyrin domain containing 2
  NLR family pyrin domain containing 4
  notch receptor 3
  nuclear factor kappa B subunit 1
  nuclear factor kappa B subunit 2
  nuclear receptor coactivator 3
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  nuclear receptor subfamily 2 group C member 2
  PAF1 homolog, Paf1/RNA polymerase II complex component
  paired box 8
  phosphatase and tensin homolog
  phosphatidylethanolamine binding protein 1
  pregnancy specific beta-1-glycoprotein 1
  proteasome 26S subunit, non-ATPase 9
  protein inhibitor of activated STAT 1
  protein kinase C alpha
  protein kinase C beta
  protein kinase C delta
  protein kinase C iota
  protein kinase C theta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 4 catalytic subunit
  protein phosphatase 4 regulatory subunit 1
  protein phosphatase 4 regulatory subunit 2
  protein phosphatase, Mg2+/Mn2+ dependent 1B
  protein tyrosine phosphatase non-receptor type 11
  PYD and CARD domain containing
  receptor interacting serine/threonine kinase 1
  receptor interacting serine/threonine kinase 2
  regulatory associated protein of MTOR complex 1
  RELA proto-oncogene, NF-kB subunit
  ribosomal protein L27
  ring finger protein 8
  RPTOR independent companion of MTOR complex 2
  SAM and SH3 domain containing 1
  SHANK associated RH domain interactor
  SHC adaptor protein 4
  signal transducing adaptor family member 2
  SMAD family member 2
  SMAD family member 3
  spermatogenesis associated 2
  S-phase kinase associated protein 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRSF protein kinase 1
  SRSF protein kinase 2
  STIP1 homology and U-box containing protein 1
  survival of motor neuron 1, telomeric
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  TNF alpha induced protein 3
  TNF receptor associated factor 1
  TNF receptor associated factor 2
  TNF receptor associated factor 4
  TNF receptor associated factor 6
  TNF receptor superfamily member 1A
  TNF receptor superfamily member 1B
  TNFAIP3 interacting protein 2
  TNFRSF1A associated via death domain
  TPX2 microtubule nucleation factor
  TRAF family member associated NFKB activator
  TRAF3 interacting protein 2
  transferrin receptor
  transforming growth factor beta receptor 1
  transient receptor potential cation channel subfamily C member 4 associated protein
  tripartite motif containing 22
  tripartite motif containing 27
  tripartite motif containing 40
  tumor necrosis factor
  tumor protein p53
  tumor protein p63
  tumor protein p73
  ubiquitin C
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 N
  ubiquitin specific peptidase 18

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.