DARS1, aspartyl-tRNA synthetase 1

DARS1, aspartyl-tRNA synthetase 1

• This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

• Gene Synonyms (aspartate--tRNA ligase, cytoplasmic, aspartate tRNA ligase 1, cytoplasmic, aspartyl-tRNA synthetase, cytoplasmic, cell proliferation-inducing gene 40 protein, testicular tissue protein Li 192, DARS, HBSL, aspRS,)
• NCBI Gene ID: 1615
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P14868
  UNIPROT ID#>>A0A140VJW5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aspartyl-tRNA synthetase 1 interacts with:

• 3-hydroxy-3-methylglutaryl-CoA synthase 1
  AAR2 splicing factor
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  anterior gradient 2, protein disulphide isomerase family member
  arginyl-tRNA synthetase 1
  aspartyl-tRNA synthetase 1
  ataxin 3
  Bet1 golgi vesicular membrane trafficking protein
  catechol-O-methyltransferase domain containing 1
  cell division cycle 16
  coenzyme Q2, polyprenyltransferase
  coiled-coil domain containing 8
  cullin 1
  cullin 3
  cullin 4A
  cullin 5
  cullin 7
  cytokine induced apoptosis inhibitor 1
  dihydrolipoamide dehydrogenase
  dihydrolipoamide S-succinyltransferase
  dynamin 1 like
  elongation factor Tu GTP binding domain containing 2
  epidermal growth factor receptor
  estrogen receptor 1
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 delta
  eukaryotic translation elongation factor 1 epsilon 1
  eukaryotic translation initiation factor 2 subunit alpha
  F-box protein 25
  F-box protein 6
  fibroblast growth factor 11
  fibronectin 1
  forkhead box B1
  forkhead box I2
  forkhead box M1
  gem nuclear organelle associated protein 4
  general transcription factor IIIC subunit 3
  glutamine--fructose-6-phosphate transaminase 1
  glutaminyl-tRNA synthetase 1
  glutamyl-prolyl-tRNA synthetase 1
  glycyl-tRNA synthetase 1
  growth factor receptor bound protein 2
  heat shock protein family A (Hsp70) member 8
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  hydroxysteroid 17-beta dehydrogenase 10
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 4
  isoleucyl-tRNA synthetase 1
  Jun proto-oncogene, AP-1 transcription factor subunit
  kinectin 1
  KRAS proto-oncogene, GTPase
  La ribonucleoprotein 7, transcriptional regulator
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucyl-tRNA synthetase 1
  leukocyte receptor cluster member 1
  lysyl-tRNA synthetase 1
  membrane bound transcription factor peptidase, site 2
  methionyl-tRNA synthetase 1
  minichromosome maintenance complex component 2
  MYC proto-oncogene, bHLH transcription factor
  neurofibromin 2
  neurotrophic receptor tyrosine kinase 1
  N-myc downstream regulated 1
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  OTU deubiquitinase 6A
  pelota mRNA surveillance and ribosome rescue factor
  phosphoinositide-3-kinase regulatory subunit 3
  pleckstrin homology domain containing A4
  prefoldin subunit 5
  pre-mRNA processing factor 8
  prohibitin
  proteasome 20S subunit alpha 5
  proteasome 26S subunit, non-ATPase 14
  protein kinase N2
  protein tyrosine phosphatase non-receptor type 6
  RAD18 E3 ubiquitin protein ligase
  RecQ like helicase 4
  regulator of MON1-CCZ1
  replication protein A2
  ribosomal protein L13
  ribosomal protein L15
  ribosomal protein L21
  ribosomal protein L23a
  ribosomal protein L26
  ribosomal protein L27a
  ribosomal protein L3
  ribosomal protein L36
  ribosomal protein L7a
  ribosomal protein lateral stalk subunit P0
  RIO kinase 1
  RNA polymerase III subunit A
  serologically defined colon cancer antigen 8
  small nuclear RNA activating complex polypeptide 1
  snail family transcriptional repressor 1
  SprT-like N-terminal domain
  staufen double-stranded RNA binding protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  superoxide dismutase 1
  syndecan binding protein
  talin 1
  thymopoietin
  TIAM Rac1 associated GEF 1
  treacle ribosome biogenesis factor 1
  tripartite motif containing 28
  tRNA methyltransferase 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin like modifier activating enzyme 2
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 7
  vascular cell adhesion molecule 1
  vesicle trafficking 1
  VHL binding protein 1
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  WW domain containing E3 ubiquitin protein ligase 2
  X-prolyl aminopeptidase 1
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.