DLST, dihydrolipoamide S-succinyltransferase

DLST, dihydrolipoamide S-succinyltransferase

• This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

• Gene Synonyms (dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial, E2K, OGDC-E2, dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), DLTS, KGD2, PGL7,)
• NCBI Gene ID: 1743
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R6C9
  UNIPROT ID#>>B7Z6J1
  UNIPROT ID#>>P36957
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dihydrolipoamide S-succinyltransferase interacts with:

• acyl-CoA thioesterase 9
  adaptor related protein complex 3 subunit delta 1
  A-kinase anchoring protein 17A
  alanyl-tRNA synthetase 2, mitochondrial
  apoptosis inducing factor mitochondria associated 1
  apoptotic chromatin condensation inducer 1
  ariadne RBR E3 ubiquitin protein ligase 2
  ASH2 like, histone lysine methyltransferase complex subunit
  ataxin 3
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3C
  aurora kinase A interacting protein 1
  BAG cochaperone 2
  bolA family member 2
  bolA family member 2B
  bromodomain containing 7
  bromodomain PHD finger transcription factor
  caspase activity and apoptosis inhibitor 1
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 7
  charged multivesicular body protein 2A
  charged multivesicular body protein 4B
  chromatin target of PRMT1
  cingulin
  coiled-coil domain containing 80
  coiled-coil domain containing 86
  coiled-coil-helix-coiled-coil-helix domain containing 3
  COPI coat complex subunit zeta 1
  coronin 1C
  crooked neck pre-mRNA splicing factor 1
  CWC15 spliceosome associated protein homolog
  cysteine and histidine rich domain containing 1
  cytochrome c oxidase assembly factor COX14
  cytoskeleton associated protein 4
  DEAD-box helicase 23
  desmoglein 2
  desmoplakin
  DExD-box helicase 21
  dihydrolipoamide S-succinyltransferase
  discs large MAGUK scaffold protein 5
  DNA topoisomerase I
  DNA topoisomerase II alpha
  DNA topoisomerase II beta
  dual specificity phosphatase 13
  dual specificity tyrosine phosphorylation regulated kinase 2
  dynein cytoplasmic 1 heavy chain 1
  electron transfer flavoprotein subunit beta
  emerin
  enolase 3
  estrogen receptor 2
  eukaryotic translation elongation factor 1 delta
  eukaryotic translation elongation factor 1 gamma
  eukaryotic translation elongation factor 2
  eukaryotic translation initiation factor 2 alpha kinase 2
  eukaryotic translation initiation factor 4 gamma 1
  eukaryotic translation initiation factor 4A3
  eukaryotic translation initiation factor 5A
  FA complementation group D2
  fascin actin-bundling protein 1
  fatty acid synthase
  fibrillarin
  FLII actin remodeling protein
  flotillin 1
  flotillin 2
  FMRP translational regulator 1
  G protein nucleolar 3
  G protein-coupled receptor kinase 5
  gap junction protein beta 1
  GAR1 ribonucleoprotein
  gelsolin
  glutamyl-prolyl-tRNA synthetase 1
  glutathione S-transferase pi 1
  H1.0 linker histone
  H1.10 linker histone
  H2A clustered histone 4
  H2A clustered histone 7
  H2A clustered histone 8
  H2A.Z variant histone 2
  heat shock protein 90 beta family member 1
  heat shock protein family B (small) member 1
  heat shock protein family D (Hsp60) member 1
  hemoglobin subunit alpha 1
  hemoglobin subunit alpha 2
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A1 like 2
  heterogeneous nuclear ribonucleoprotein H3
  high mobility group AT-hook 2
  histone deacetylase 6
  histone deacetylase 6
  HPS5 biogenesis of lysosomal organelles complex 2 subunit 2
  hydroxysteroid 17-beta dehydrogenase 10
  hydroxysteroid 17-beta dehydrogenase 4
  hydroxysteroid dehydrogenase like 2
  hypoxia up-regulated 1
  inner membrane mitochondrial protein
  inosine monophosphate dehydrogenase 2
  integrin alpha FG-GAP repeat containing 1
  interleukin enhancer binding factor 2
  internexin neuronal intermediate filament protein alpha
  karyopherin subunit beta 1
  kinesin family member 5B
  lactate dehydrogenase B
  lamin A/C
  lamin B receptor
  lamin B1
  lamin B2
  LUC7 like
  lysine rich nucleolar protein 1
  macroH2A.1 histone
  macroH2A.2 histone
  MAGE family member D2
  major histocompatibility complex, class I, A
  malate dehydrogenase 2
  malectin
  mediator of DNA damage checkpoint 1
  metastasis associated 1
  metastasis associated 1 family member 2
  methionyl-tRNA synthetase 1
  minichromosome maintenance complex component 3
  mitochondrial ribosomal protein L12
  mitochondrial ribosomal protein L15
  mitochondrial ribosomal protein L2
  mitochondrial ribosomal protein L39
  mitochondrial ribosomal protein L40
  mitochondrial ribosomal protein S11
  mitochondrial ribosomal protein S14
  mitochondrial ribosomal protein S17
  mitochondrial rRNA methyltransferase 1
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 11
  myosin heavy chain 14
  myosin IB
  myosin IC
  myosin ID
  myosin light chain 1
  myosin VI
  myosin XVIIIA
  NADH:ubiquinone oxidoreductase subunit B1
  neurolysin
  neutrophil cytosolic factor 1
  NHP2 ribonucleoprotein
  N-myc downstream regulated 1
  NOC3 like DNA replication regulator
  NOP10 ribonucleoprotein
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  nuclear receptor coactivator 5
  nuclear receptor subfamily 3 group C member 1
  nucleoporin 93
  nucleoside-triphosphatase, cancer-related
  nucleosome assembly protein 1 like 1
  ornithine aminotransferase
  oxoglutarate dehydrogenase
  p21 (RAC1) activated kinase 4
  peptidylprolyl isomerase A
  peptidylprolyl isomerase A like 4A
  peripherin
  peroxiredoxin 3
  PHD and ring finger domains 1
  phosphatidylinositol binding clathrin assembly protein
  phosphogluconate dehydrogenase
  phosphoglycerate mutase 1
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  pinin, desmosome associated protein
  plectin
  pleiotropic regulator 1
  poly(A) binding protein cytoplasmic 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 38A
  pre-mRNA processing factor 6
  profilin 1
  profilin 2
  programmed cell death 6 interacting protein
  prohibitin
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 4
  protein disulfide isomerase family A member 3
  protein disulfide isomerase family A member 6
  protein phosphatase 2 scaffold subunit Aalpha
  protein-L-isoaspartate (D-aspartate) O-methyltransferase
  pyrroline-5-carboxylate reductase 2
  pyruvate dehydrogenase E1 subunit beta
  pyruvate dehydrogenase kinase 1
  RAB, member RAS oncogene family like 6
  RAB11 family interacting protein 2
  RAB1A, member RAS oncogene family
  RAB1B, member RAS oncogene family
  RAB5A, member RAS oncogene family
  RAB5C, member RAS oncogene family
  RAB7A, member RAS oncogene family
  RAD50 double strand break repair protein
  RALY RNA binding protein like
  RAN binding protein 1
  Ran GTPase activating protein 1
  RAP1A, member of RAS oncogene family
  RBMX like 2
  RecQ like helicase 4
  ribophorin I
  ribophorin II
  ribosomal protein L30
  ribosome binding protein 1
  RNA binding motif protein 4
  RNA binding motif protein 8A
  RNA binding protein with serine rich domain 1
  RUN and SH3 domain containing 2
  scaffold attachment factor B
  sec1 family domain containing 1
  sequestosome 1
  siah E3 ubiquitin protein ligase 2
  sideroflexin 1
  sideroflexin 3
  signal recognition particle 68
  Sin3A associated protein 18
  small nuclear ribonucleoprotein 13
  solute carrier family 25 member 13
  splicing factor 3b subunit 6
  splicing factor SWAP
  staphylococcal nuclease and tudor domain containing 1
  stomatin like 2
  succinate-CoA ligase ADP-forming subunit beta
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  TATA-box binding protein associated factor 5
  tau tubulin kinase 1
  Tax1 binding protein 1
  THO complex 1
  thymopoietin
  thyroid hormone receptor associated protein 3
  tight junction protein 1
  TNF receptor associated protein 1
  TNFAIP3 interacting protein 2
  trans-2,3-enoyl-CoA reductase
  transgelin 2
  translocase of outer mitochondrial membrane 22
  transporter 1, ATP binding cassette subfamily B member
  trinucleotide repeat containing adaptor 6C
  triosephosphate isomerase 1
  tripartite motif containing 28
  tRNA methyltransferase 61B
  tropomyosin 1
  tropomyosin 4
  Ts translation elongation factor, mitochondrial
  tubulin beta 4B class IVb
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 D2
  ubiquitin C-terminal hydrolase L1
  ubiquitin interaction motif containing 1
  ubiquitin like modifier activating enzyme 1
  ubiquitin specific peptidase 13
  uridine monophosphate synthetase
  vir like m6A methyltransferase associated
  voltage dependent anion channel 2
  X-ray repair cross complementing 6
  YTH domain containing 1
  zinc finger and BTB domain containing 16
  zinc finger protein 512
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.