DDX6, DEAD-box helicase 6

DDX6, DEAD-box helicase 6

• This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

• Gene Synonyms (probable ATP-dependent RNA helicase DDX6, ATP-dependent RNA helicase p54, DEAD (Asp-Glu-Ala-Asp) box helicase 6, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6, DEAD box protein 6, DEAD box-6, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD), oncogene RCK, HLR2, IDDILF, P54, RCK, Rck/p54,)
• NCBI Gene ID: 1656
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P26196
  UNIPROT ID#>>B2R858
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DEAD-box helicase 6 interacts with:

• 2'-5'-oligoadenylate synthetase like
  AF4/FMR2 family member 1
  anterior gradient 2, protein disulphide isomerase family member
  argonaute RISC catalytic component 2
  ataxin 2
  ataxin 2 like
  ataxin 3
  baculoviral IAP repeat containing 7
  BAG cochaperone 4
  basic helix-loop-helix family member b9
  BEN domain containing 7
  brain enriched guanylate kinase associated
  bromodomain containing 7
  calcium binding and coiled-coil domain 2
  CCR4-NOT transcription complex subunit 1
  CCR4-NOT transcription complex subunit 7
  centrosomal protein 70
  centrosomal protein 76
  CNKSR family member 3
  coiled-coil domain containing 136
  coiled-coil domain containing 14
  COMM domain containing 4
  COP9 signalosome subunit 5
  cullin 3
  cullin 7
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 17
  decapping mRNA 1A
  decapping mRNA 1B
  decapping mRNA 2
  desmin
  DISC1 scaffold protein
  E1A binding protein p300
  EF-hand domain containing 2
  electron transfer flavoprotein subunit alpha
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  endosome associated trafficking regulator 1
  enhancer of mRNA decapping 3
  enhancer of mRNA decapping 4
  enhancer of mRNA decapping 4
  estrogen receptor 2
  eukaryotic translation initiation factor 4E nuclear import factor 1
  exportin 1
  ezrin
  F-box protein 6
  FCH and mu domain containing endocytic adaptor 1
  fibronectin 1
  FMR1 autosomal homolog 1
  G3BP stress granule assembly factor 1
  G3BP stress granule assembly factor 2
  golgin A2
  GRB10 interacting GYF protein 1
  heterogeneous nuclear ribonucleoprotein A1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  hook microtubule tethering protein 2
  IK cytokine
  IKAROS family zinc finger 1
  inka box actin regulator 1
  inositol polyphosphate phosphatase like 1
  integrin alpha FG-GAP repeat containing 1
  janus kinase and microtubule interacting protein 1
  junction plakoglobin
  keratin 34
  keratin 40
  keratin associated protein 10-3
  keratin associated protein 10-8
  kinesin light chain 4
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat containing 6
  leucine zipper like transcription regulator 1
  leucine zipper tumor suppressor 1
  LSM family member 14B
  LSM12 homolog
  LSM14A mRNA processing body assembly factor
  LSM14A mRNA processing body assembly factor
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  mab-21 like 2
  MAGE family member D1
  MAPK regulated corepressor interacting protein 1
  MAPK regulated corepressor interacting protein 2
  mesoderm development LRP chaperone
  methylphosphate capping enzyme
  microtubule associated protein tau
  microtubule associated scaffold protein 2
  minichromosome maintenance complex component 2
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  NGFI-A binding protein 2
  non-POU domain containing octamer binding
  nuclear FMR1 interacting protein 2
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  obscurin like cytoskeletal adaptor 1
  p21 (RAC1) activated kinase 4
  p21 (RAC1) activated kinase 5
  PAT1 homolog 1, processing body mRNA decay factor
  PDZ and LIM domain 7
  peptidylprolyl isomerase A
  peptidylprolyl isomerase domain and WD repeat containing 1
  peptidylprolyl isomerase E
  peripherin
  Pim-1 proto-oncogene, serine/threonine kinase
  pleckstrin homology domain containing A4
  PNMA family member 5
  poly(rC) binding protein 1
  POU class 6 homeobox 2
  PR/SET domain 16
  prohibitin
  proline rich nuclear receptor coactivator 1
  protein interacting with PRKCA 1
  PTEN induced kinase 1
  Rap guanine nucleotide exchange factor 3
  RecQ like helicase 4
  REL proto-oncogene, NF-kB subunit
  Rho GTPase activating protein 17
  ribosomal protein S6 kinase B2
  ribosome binding protein 1
  ring finger and CCCH-type domains 1
  RNA binding motif protein 11
  RNA binding motif protein 14
  RNA polymerase I subunit E
  RUN domain containing 3A
  SCY1 like pseudokinase 1
  serine hydroxymethyltransferase 1
  SH3 domain containing ring finger 2
  signal induced proliferation associated 1 like 2
  signal regulatory protein alpha
  signal transducer and activator of transcription 1
  SLAIN motif family member 1
  small nuclear ribonucleoprotein U1 subunit 70
  sorbin and SH3 domain containing 3
  spermatogenesis associated 6
  SRSF protein kinase 2
  TAR DNA binding protein
  thyroid hormone receptor interactor 4
  TNF receptor associated factor 2
  transcription factor 12
  transcription factor 4
  translocase of inner mitochondrial membrane 13
  translocase of inner mitochondrial membrane 8 homolog B
  trinucleotide repeat containing adaptor 6A
  tripartite motif containing 25
  tripartite motif containing 27
  tripartite motif containing 28
  tripartite motif containing 37
  tripartite motif containing 54
  tumor protein p53 binding protein 2
  tumor susceptibility 101
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquitin associated and SH3 domain containing B
  ubiquitin specific peptidase 14
  USH1 protein network component sans
  vascular cell adhesion molecule 1
  VPS52 subunit of GARP complex
  WD repeat domain 12
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  zinc finger and BTB domain containing 10
  zinc finger and BTB domain containing 14
  zinc finger and BTB domain containing 43
  zinc finger and BTB domain containing 8A
  zinc finger C2HC-type containing 1C
  zinc finger CCCH-type containing 7A
  zinc finger protein 24
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.