DES, desmin

DES, desmin

• This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]

• Gene Synonyms (desmin, cardiomyopathy, dilated 1F (autosomal dominant), epididymis secretory sperm binding protein, intermediate filament protein, CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R,)
• NCBI Gene ID: 1674
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P17661
  UNIPROT ID#>>Q53SB5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

desmin interacts with:

• aurora kinase B
  BAG cochaperone 5
  cancer/testis antigen 55
  chaperonin containing TCP1 subunit 7
  chromosome 1 open reading frame 216
  CWF19 like cell cycle control factor 2
  desmin
  desmoplakin
  dihydrolipoamide S-succinyltransferase
  enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
  GLI family zinc finger 1
  glial fibrillary acidic protein
  golgin A6 family like 9
  heat shock protein family B (small) member 1
  heterogeneous nuclear ribonucleoprotein U like 1
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  intersectin 1
  junction plakoglobin
  keratin 13
  keratin 15
  keratin 20
  keratin 33B
  keratin 37
  keratin 75
  ladybird homeobox 1
  leukocyte receptor cluster member 1
  LIM domain only 4
  LON peptidase N-terminal domain and ring finger 3
  MAPK activated protein kinase 2
  meiosis 1 associated protein
  Mov10 RISC complex RNA helicase
  mutL homolog 1
  myosin light chain 6
  nebulin
  neurofilament light
  neurofilament medium
  NIMA related kinase 6
  peripherin
  periplakin
  PIH1 domain containing 2
  pleckstrin homology domain containing A5
  polycystin 1, transient receptor potential channel interacting
  protein inhibitor of activated STAT 2
  protein phosphatase 1 regulatory subunit 18
  pyruvate dehydrogenase E1 subunit alpha 1
  Rho associated coiled-coil containing protein kinase 1
  ribosomal protein L17
  ribosomal protein L29
  ring finger protein 4
  RNA polymerase II subunit G
  S100 calcium binding protein A1
  S100 calcium binding protein B
  sex hormone binding globulin
  small nuclear ribonucleoprotein U1 subunit 70
  Sp1 transcription factor
  spectrin alpha, non-erythrocytic 1
  spermatogenesis associated 22
  superoxide dismutase 1
  syncoilin, intermediate filament protein
  synemin
  transcription elongation factor A2
  tripartite motif containing 55
  tripartite motif containing 63
  tripartite motif containing 7
  tuftelin interacting protein 11
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin conjugating enzyme E2 I
  valosin containing protein
  vimentin
  YES proto-oncogene 1, Src family tyrosine kinase
  zinc finger MYM-type containing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.