GATA4, GATA binding protein 4

GATA4, GATA binding protein 4

• This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (ASD2, TACHD, TOF, VSD1, transcription factor GATA-4, GATA-binding factor 4,)
• NCBI Gene ID: 2626
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B6DU75
  UNIPROT ID#>>B3KUF4
  UNIPROT ID#>>P43694
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

GATA binding protein 4 interacts with:

• ALX homeobox 4
  cyclin-dependent kinase 9 (CDC2-related kinase)
  E1A binding protein p300
  heart and neural crest derivatives expressed 2
  histone deacetylase 2
  inhibitor of DNA binding 1, HLH protein
  inhibitor of DNA binding 2
  inhibitor of DNA binding 3, HLH protein
  jumonji and AT-rich interaction domain containing 2
  lysine demethylase 6A
  mediator complex subunit 1
  mediator of DNA damage checkpoint 1
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  myocyte enhancer factor 2C
  nuclear factor of activated T cells 4
  protein inhibitor of activated STAT 1
  receptor for activated C kinase 1
  serum response factor
  Sp1 transcription factor
  SRY-box transcription factor 2
  SUZ12 polycomb repressive complex 2 subunit
  T-box transcription factor 5
  zinc finger and BTB domain containing 3
  zinc finger protein, FOG family member 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.