KAT2A, lysine acetyltransferase 2A

KAT2A, lysine acetyltransferase 2A

• KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

• Gene Synonyms (GCN5, GCN5L2, PCAF-b, hGCN5, histone acetyltransferase KAT2A, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2, General control of amino acid synthesis, yeast, homolog-like 2, K(lysine) acetyltransferase 2A, STAF97, general control of amino acid synthesis protein 5-like 2, histone acetyltransferase GCN5, histone glutaryltransferase KAT2A, histone succinyltransferase KAT2A, hsGCN5,)
• NCBI Gene ID: 2648
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92830
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lysine acetyltransferase 2A interacts with:

• adenosine deaminase tRNA specific 3
  ataxin 7
  ataxin 7 like 3
  basic leucine zipper ATF-like transcription factor 2
  beclin 1
  copper metabolism domain containing 1
  cullin 2
  cullin 4A
  denticleless E3 ubiquitin protein ligase homolog
  ENY2 transcription and export complex 2 subunit
  EP300 interacting inhibitor of differentiation 1
  fizzy and cell division cycle 20 related 1
  glutamate metabotropic receptor 1
  H1.5 linker histone, cluster member
  H2A clustered histone 20
  H2A.X variant histone
  H2B clustered histone 21
  H3 clustered histone 1
  H3 clustered histone 14
  H3.3 histone A
  H3.4 histone
  H4 clustered histone 1
  H4 clustered histone 14
  H4 histone 16
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  heparin binding growth factor
  hydroxysteroid 11-beta dehydrogenase 2
  IKAROS family zinc finger 5
  interferon regulatory factor 1
  interferon regulatory factor 2
  interferon regulatory factor 7
  KDEL endoplasmic reticulum protein retention receptor 2
  keratin 2
  lactate dehydrogenase A
  large tumor suppressor kinase 2
  lysine acetyltransferase 14
  lysine acetyltransferase 2A
  MAGE family member A10
  MAP3K12 binding inhibitory protein 1
  mediator complex subunit 1
  mediator complex subunit 12
  mediator complex subunit 16
  mediator complex subunit 17
  mitogen-activated protein kinase 8 interacting protein 3
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase kinase 7
  MYB proto-oncogene, transcription factor
  MYC associated factor X
  MYC proto-oncogene, bHLH transcription factor
  myelocytomatosis oncogene
  neurofibromin 2
  NME/NM23 nucleoside diphosphate kinase 1
  notch 1
  notch receptor 1
  pancreas associated transcription factor 1a
  PBX homeobox 1
  peroxisome proliferator activated receptor gamma
  placenta enriched 1
  poly(rC) binding protein 2
  PPARG coactivator 1 alpha
  prostaglandin E synthase 3
  protein kinase, DNA-activated, catalytic subunit
  pygopus family PHD finger 2
  Ras association domain family member 1
  recombination signal binding protein for immunoglobulin kappa J region
  RELA proto-oncogene, NF-kB subunit
  ribonucleic acid export 1
  SAGA complex associated factor 29
  serine/threonine kinase 11
  sirtuin 1
  sirtuin 2
  SMAD family member 1
  SMAD family member 2
  SMAD family member 3
  SMAD family member 5
  SMAD family member 9
  splicing factor 3b subunit 3
  SPT20 homolog, SAGA complex component
  SPT3 homolog, SAGA and STAGA complex component
  SPT7 like, STAGA complex subunit gamma
  sterol regulatory element binding transcription factor 1
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 3
  TATA-box binding protein associated factor 4
  TATA-box binding protein associated factor 5 like
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 6 like
  TATA-box binding protein associated factor 9
  TATA-box binding protein associated factor 9b
  TIR domain containing adaptor protein
  transcription factor 3
  transcriptional adaptor 1
  transcriptional adaptor 2A
  transcriptional adaptor 3
  transformation/transcription domain associated protein
  transforming acidic coiled-coil containing protein 1
  transforming acidic coiled-coil containing protein 2
  transforming acidic coiled-coil containing protein 3
  TSC complex subunit 1
  tubulin beta class I
  tumor protein p53
  tumor protein p53 binding protein 1
  tweety family member 2
  ubiquitin associated protein 2 like
  ubiquitin conjugating enzyme E2 I
  ubiquitin specific peptidase 22
  WD repeat and HMG-box DNA binding protein 1
  WD repeat domain 5
  X-box binding protein 1
  X-ray repair cross complementing 5
  YEATS domain containing 2
  zinc finger protein 148
  zinc finger ZZ-type containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.