PPEF1, protein phosphatase with EF-hand domain 1

PPEF1, protein phosphatase with EF-hand domain 1

• This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (serine/threonine-protein phosphatase with EF-hands 1, protein phosphatase 7, catalytic subunit, alpha isozyme, protein phosphatase with EF calcium-binding domain, protein phosphatase, EF-hand calcium binding domain 1, protein phosphatase, serine/threonine type, with EF-hands, serine/threonine protein phosphatase 7, PP7, PPEF, PPP7C, PPP7CA,)
• NCBI Gene ID: 5475
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14829
  UNIPROT ID#>>A0A024RBZ9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein phosphatase with EF-hand domain 1 interacts with:

• A-kinase anchoring protein 8
  apoptosis inducing factor mitochondria associated 1
  ATPase family AAA domain containing 3A
  BAG cochaperone 2
  cell cycle and apoptosis regulator 2
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member C7
  elongation factor Tu GTP binding domain containing 2
  HCLS1 associated protein X-1
  heat shock protein family H (Hsp110) member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  ilvB acetolactate synthase like
  insulin receptor substrate 4
  leucine rich pentatricopeptide repeat containing
  nucleoside-triphosphatase, cancer-related
  phosphohistidine phosphatase 1
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase with EF-hand domain 1
  ribophorin I
  ribophorin II
  ribosomal protein L38
  SEC16 homolog A, endoplasmic reticulum export factor
  signal sequence receptor subunit 1
  signal sequence receptor subunit 4
  solute carrier family 25 member 13
  spectrin repeat containing nuclear envelope protein 1
  synthesis of cytochrome C oxidase 1
  synthesis of cytochrome C oxidase 2
  translocase of inner mitochondrial membrane 50
  Tu translation elongation factor, mitochondrial
  tubulin beta 2A class IIa
  tubulin beta 2B class IIb
  tubulin beta 4A class IVa
  tubulin beta 4B class IVb
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  ubiquitin protein ligase E3 component n-recognin 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.