EIF4E, eukaryotic translation initiation factor 4E

EIF4E, eukaryotic translation initiation factor 4E

• The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

• Gene Synonyms (AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E, eukaryotic translation initiation factor 4E, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E-like 1, mRNA cap-binding protein,)
• NCBI Gene ID: 1977
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q32Q75
  UNIPROT ID#>>X5D7E3
  UNIPROT ID#>>D6RBW1
  UNIPROT ID#>>P06730
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 4E interacts with:

• activator of HSP90 ATPase activity 1
  angel homolog 1
  CD83 molecule
  DEAD-box helicase 19A
  Ecm29 proteasome adaptor and scaffold
  ELAV like RNA binding protein 1
  elongation factor Tu GTP binding domain containing 2
  empty spiracles homeobox 2
  estrogen receptor 2
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit B
  eukaryotic translation initiation factor 3 subunit F
  eukaryotic translation initiation factor 3, subunit A
  eukaryotic translation initiation factor 4 gamma 1
  eukaryotic translation initiation factor 4 gamma 2
  eukaryotic translation initiation factor 4 gamma 3
  eukaryotic translation initiation factor 4E
  eukaryotic translation initiation factor 4E binding protein 1
  eukaryotic translation initiation factor 4E binding protein 2
  eukaryotic translation initiation factor 4E binding protein 3
  eukaryotic translation initiation factor 4E nuclear import factor 1
  eukaryotic translation initiation factor 4H
  eukaryotic translation initiation factor 6
  FMRP translational regulator 1
  gem nuclear organelle associated protein 5
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 2
  heat shock protein family D (Hsp60) member 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  integrin subunit alpha 4
  KN motif and ankyrin repeat domains 2
  MAPK activated protein kinase 5
  MAPK interacting serine/threonine kinase 1
  MAPK interacting serine/threonine kinase 2
  mechanistic target of rapamycin kinase
  methyltransferase like 3
  N-acetylneuraminate synthase
  neurotrophic receptor tyrosine kinase 1
  NFKB inhibitor zeta
  nuclear transcription factor, X-box binding 1
  OTU deubiquitinase 6B
  peptidase D
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PML nuclear body scaffold
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 3
  poly(A) binding protein cytoplasmic 4
  PR/SET domain 4
  protein kinase C alpha
  protein kinase C beta
  protein kinase C gamma
  pyridoxal kinase
  pyridoxal phosphate binding protein
  pyrin and HIN domain family member 1
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  ribosomal protein S6 kinase B1
  ring finger protein 123
  serine and arginine rich splicing factor 3
  STIP1 homology and U-box containing protein 1
  tripartite motif containing 22
  tripartite motif containing 27
  tryptophan 2,3-dioxygenase
  ubiquitin family domain containing 1
  UBX domain protein 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.