EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1

EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1

• This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (4E-BP1, 4EBP1, BP-1, PHAS-I, eukaryotic translation initiation factor 4E-binding protein 1, eIF4E-binding protein 1, phosphorylated heat- and acid-stable protein regulated by insulin 1,)
• NCBI Gene ID: 1978
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13541
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 4E binding protein 1 interacts with:

• AKT serine/threonine kinase 3
  argonaute RISC catalytic component 2
  charged multivesicular body protein 2A
  chromosome transmission fidelity factor 8
  DNA damage inducible transcript 4 like
  eukaryotic translation initiation factor 4E family member 1B
  eukaryotic translation initiation factor 4E family member 2
  filamin B
  glycogen synthase kinase 3 beta
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein A1
  interleukin 1 receptor associated kinase 4
  kelch like family member 25
  large tumor suppressor kinase 1
  LDL receptor related protein associated protein 1
  leucine rich repeat kinase 2
  LIM domain only 2
  MAPK activated protein kinase 5
  mechanistic target of rapamycin kinase
  mesenchyme homeobox 1
  mevalonate diphosphate decarboxylase
  mitogen-activated protein kinase 1
  MTOR associated protein, LST8 homolog
  POU class 6 homeobox 2
  protein interacting with PRKCA 1
  protein kinase C alpha
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 regulatory subunit Balpha
  RAR related orphan receptor C
  regulatory associated protein of MTOR complex 1
  REL proto-oncogene, NF-kB subunit
  RHEB like 1
  ribosomal protein S6 kinase A5
  ribosomal protein S6 kinase B1
  RPTOR independent companion of MTOR complex 2
  sarcolemma associated protein
  serine hydroxymethyltransferase 2
  serine/threonine kinase 3
  transcription factor 4
  tripartite motif containing 14
  tripartite motif containing 25
  UBA domain containing 1
  YJU2 splicing factor homolog
  zinc finger protein 655

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