ERCC4, ERCC excision repair 4, endonuclease catalytic subunit

ERCC4, ERCC excision repair 4, endonuclease catalytic subunit

• The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]

• Gene Synonyms (ERCC11, FANCQ, RAD1, XFEPS, XPF, DNA repair endonuclease XPF, DNA excision repair protein ERCC-4, DNA repair protein complementing XP-F cells, excision repair cross-complementation group 4, excision repair cross-complementing rodent repair deficiency, complementation group 4, excision-repair, complementing defective, in Chinese hamster, xeroderma pigmentosum group F-complementing protein, xeroderma pigmentosum, complementation group F,)
• NCBI Gene ID: 2072
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92889
  UNIPROT ID#>>A0A1W1GSK9
  UNIPROT ID#>>B4DXD8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ERCC excision repair 4, endonuclease catalytic subunit interacts with:

• Aly/REF export factor
  damage specific DNA binding protein 1
  egl-9 family hypoxia inducible factor 3
  ERCC excision repair 4, endonuclease catalytic subunit
  ERCC excision repair 6, chromatin remodeling factor
  FA complementation group A
  FA complementation group D2
  FA complementation group G
  F-box protein 38
  general transcription factor IIH subunit 1
  glycophorin B (MNS blood group)
  kinesin family member 11
  kinesin light chain 2
  Ly1 antibody reactive
  mediator of DNA damage checkpoint 1
  MUS81 structure-specific endonuclease subunit
  MUS81 structure-specific endonuclease subunit
  mutS homolog 2
  neurotrophic receptor tyrosine kinase 1
  NFKB inhibitor delta
  polo like kinase 1
  RAD52 homolog, DNA repair protein
  replication protein A1
  replication protein A2
  ring finger protein 4
  RNA polymerase II subunit A
  SLX1 homolog A, structure-specific endonuclease subunit
  SLX1 homolog B, structure-specific endonuclease subunit
  SLX4 interacting protein
  SLX4 structure-specific endonuclease subunit
  SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
  small ubiquitin like modifier 2
  spectrin alpha, erythrocytic 1
  spectrin alpha, non-erythrocytic 1
  transcriptional adaptor 2A
  transforming acidic coiled-coil containing protein 1
  tumor protein p53 binding protein 1
  ubiquitin conjugating enzyme E2 B
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin specific peptidase 45
  vir like m6A methyltransferase associated
  VPS26, retromer complex component A
  XPA, DNA damage recognition and repair factor
  zinc finger C3H1-type containing

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.