FOXO3, forkhead box O3

FOXO3, forkhead box O3

• This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box protein O3, forkhead box O3A, forkhead homolog (rhabdomyosarcoma) like 1, forkhead in rhabdomyosarcoma-like 1, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1,)
• NCBI Gene ID: 2309
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43524
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

forkhead box O3 interacts with:

• autophagy related 101
  BCL2 binding component 3
  BCL2 like 11
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BICD cargo adaptor 2
  centrosomal protein 44
  chibby family member 1, beta catenin antagonist
  chromatin licensing and DNA replication factor 1
  E1A binding protein p300
  egl-9 family hypoxia inducible factor 3
  erbb2 interacting protein
  exportin 1
  forkhead box K1
  forkhead box O3B
  forkhead box O6
  H2A.X variant histone
  heterogeneous nuclear ribonucleoprotein L
  inhibitor of nuclear factor kappa B kinase subunit beta
  MDM2 proto-oncogene
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 6
  MYC proto-oncogene, bHLH transcription factor
  nemo like kinase
  nipsnap homolog 2
  nuclear receptor subfamily 1 group H member 2
  nuclear receptor subfamily 1 group H member 3
  phosphoglycerate kinase 1
  polo like kinase 1
  polynucleotide kinase 3'-phosphatase
  proliferating cell nuclear antigen
  protein phosphatase 2 catalytic subunit beta
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 scaffold subunit Aalpha
  protein phosphatase 2 scaffold subunit Abeta
  RAD17 checkpoint clamp loader component
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 1
  Rho/Rac guanine nucleotide exchange factor 2
  serine/threonine kinase 4
  serum/glucocorticoid regulated kinase 1
  sirtuin 1
  sirtuin 3
  sirtuin 6
  SMAD family member 1
  SMAD family member 2
  SMAD family member 3
  SMAD family member 4
  S-phase kinase associated protein 2
  TATA-box binding protein associated factor 5 like
  telomerase reverse transcriptase
  transformation/transcription domain associated protein
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin specific peptidase 7
  vir like m6A methyltransferase associated
  vitamin D receptor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.