IKBKB, inhibitor of nuclear factor kappa B kinase subunit beta

IKBKB, inhibitor of nuclear factor kappa B kinase subunit beta

• The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

• Gene Synonyms (inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, nuclear factor NF-kappa-B inhibitor kinase beta, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB,)
• NCBI Gene ID: 3551
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14920
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inhibitor of nuclear factor kappa B kinase subunit beta interacts with:

• angiopoietin like 8
  aurora kinase A
  BCL10 immune signaling adaptor
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BRCA1 associated protein
  calcium binding and coiled-coil domain 2
  CASP8 and FADD like apoptosis regulator
  cell cycle and apoptosis regulator 2
  cell division cycle 37
  cell division cycle 37, HSP90 cochaperone
  COMM domain containing 7
  conserved helix-loop-helix ubiquitous kinase
  COP9 signalosome subunit 3
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 7A
  CUE domain containing 2
  cullin 1
  cullin 3
  C-X-C motif chemokine ligand 8
  egl-9 family hypoxia inducible factor 3
  ELKS/RAB6-interacting/CAST family member 1
  elongator complex protein 1
  eukaryotic translation initiation factor 2 alpha kinase 2
  eukaryotic translation initiation factor 2 alpha kinase 3
  Fas associated factor 1
  glycogen phosphorylase L
  heat shock protein 90, alpha (cytosolic), class A member 1
  homer scaffold protein 3
  inhibitor of kappaB kinase gamma
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inhibitor of nuclear factor kappa B kinase subunit beta
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  insulin receptor substrate 1
  interferon induced protein with tetratricopeptide repeats 5
  interleukin 1 receptor associated kinase 1
  itchy E3 ubiquitin protein ligase
  Jun proto-oncogene, AP-1 transcription factor subunit
  kelch like ECH associated protein 1
  kelch like family member 21
  large tumor suppressor kinase 2
  leucine rich repeat containing 14
  MALT1 paracaspase
  mesenchyme homeobox 2
  metadherin
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase 11
  mitogen-activated protein kinase kinase kinase 13
  mitogen-activated protein kinase kinase kinase 14
  mitogen-activated protein kinase kinase kinase 3
  mitogen-activated protein kinase kinase kinase 7
  mono-ADP ribosylhydrolase 1
  mucin 1, cell surface associated
  N-alpha-acetyltransferase 20, NatB catalytic subunit
  NBR1 autophagy cargo receptor
  NEDD4 like E3 ubiquitin protein ligase
  nerve growth factor receptor
  NFKB inhibitor alpha
  NFKB inhibitor beta
  NLR family CARD domain containing 5
  NLR family member X1
  NLR family pyrin domain containing 2
  nuclear factor kappa B subunit 1
  nuclear factor kappa B subunit 2
  nuclear receptor coactivator 3
  nuclear receptor subfamily 2 group C member 2
  optineurin
  pellino E3 ubiquitin protein ligase 1
  peroxiredoxin 3
  peroxisome proliferator activated receptor gamma
  phosphatidylethanolamine binding protein 1
  pleckstrin homology domain containing A4
  polo like kinase 1
  pregnancy specific beta-1-glycoprotein 1
  protein kinase C alpha
  protein kinase C beta
  protein kinase C delta
  protein kinase C epsilon
  protein kinase C iota
  protein kinase C theta
  protein kinase C zeta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 regulatory subunit 15A
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 regulatory subunit B''gamma
  protein phosphatase 4 catalytic subunit
  protein phosphatase 4 regulatory subunit 1
  protein phosphatase 4 regulatory subunit 2
  protein phosphatase, Mg2+/Mn2+ dependent 1B
  PYD and CARD domain containing
  RAN, member RAS oncogene family
  receptor interacting serine/threonine kinase 1
  regulatory associated protein of MTOR complex 1
  RELA proto-oncogene, NF-kB subunit
  Rho associated coiled-coil containing protein kinase 1
  ring finger protein 8
  RPTOR independent companion of MTOR complex 2
  SAM and SH3 domain containing 1
  sequestosome 1
  serine/threonine kinase 26
  SHANK associated RH domain interactor
  signal transducing adaptor family member 2
  solute carrier family 25 member 13
  solute carrier family 25 member 22
  spermatogenesis associated 2
  S-phase kinase associated protein 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  survival of motor neuron 1, telomeric
  synaptosomal-associated protein 23
  TANK binding kinase 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 3
  TNF alpha induced protein 3
  TNF receptor associated factor 1
  TNF receptor associated factor 2
  TNF receptor associated factor 6
  TNF receptor superfamily member 1A
  TNFAIP3 interacting protein 2
  toll interacting protein
  TPX2 microtubule nucleation factor
  TRAF family member associated NFKB activator
  TRAF2 and NCK interacting kinase
  TRAF3 interacting protein 2
  trafficking protein particle complex 9
  transcription factor AP-2 gamma
  transferrin receptor
  transferrin receptor
  transforming growth factor beta receptor 1
  transient receptor potential cation channel subfamily C member 4 associated protein
  tripartite motif containing 21
  tripartite motif containing 27
  tripartite motif containing 40
  TSC complex subunit 1
  tumor necrosis factor
  tumor protein p53
  tumor protein p63
  tumor protein p73
  twist family bHLH transcription factor 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  ubiquitin B
  ubiquitin C
  ubiquitin specific peptidase 18
  ubiquitin specific peptidase 4
  von Hippel-Lindau tumor suppressor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.