GOT1, glutamic-oxaloacetic transaminase 1

GOT1, glutamic-oxaloacetic transaminase 1

• Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]

• Gene Synonyms (aspartate aminotransferase, cytoplasmic, aspartate aminotransferase 1, aspartate transaminase 1, cysteine aminotransferase, cytoplasmic, cysteine transaminase, cytoplasmic, glutamate oxaloacetate transaminase 1, glutamic-oxaloacetic transaminase 1, soluble, growth-inhibiting protein 18, testis secretory sperm-binding protein Li 196a, transaminase A, AST1, ASTQTL1, GIG18, cAspAT, cCAT,)
• NCBI Gene ID: 2805
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P17174
  UNIPROT ID#>>A0A140VK69
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutamic-oxaloacetic transaminase 1 interacts with:

• 3-oxoacid CoA-transferase 1
  ABI family member 3 binding protein
  aldehyde dehydrogenase 4 family member A1
  aminoadipate aminotransferase
  chromatin accessibility complex subunit 1
  chromosome 11 open reading frame 54
  coiled-coil-helix-coiled-coil-helix domain containing 4
  copper chaperone for superoxide dismutase
  dicarbonyl and L-xylulose reductase
  fumarylacetoacetate hydrolase domain containing 1
  glutamic-oxaloacetic transaminase 1 like 1
  glutamic--pyruvic transaminase 2
  glutathione-disulfide reductase
  glyoxalase domain containing 4
  heat shock protein family E (Hsp10) member 1
  HtrA serine peptidase 2
  hypoxanthine phosphoribosyltransferase 1
  isocitrate dehydrogenase (NADP(+)) 1
  kinesin family member 2C
  kynurenine aminotransferase 3
  malate dehydrogenase 1
  methylthioadenosine phosphorylase
  Mov10 RISC complex RNA helicase
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  N-acetylneuraminate synthase
  NME/NM23 nucleoside diphosphate kinase 1
  NME/NM23 nucleoside diphosphate kinase 2
  NME1-NME2 readthrough
  nuclear RNA export factor 1
  ornithine aminotransferase
  peptidase D
  peptidylprolyl isomerase like 3
  phosphatidylinositol transfer protein alpha
  phosphatidylinositol transfer protein beta
  phosphogluconate dehydrogenase
  phosphoglycerate dehydrogenase
  pirin
  programmed cell death 6 interacting protein
  prostaglandin reductase 1
  pyruvate carboxylase
  riboflavin kinase
  ribonucleic acid export 1
  SBDS ribosome maturation factor
  serine hydroxymethyltransferase 2
  sorting nexin 3
  sulfiredoxin 1
  superoxide dismutase 1
  thioredoxin reductase 2
  thymidylate synthetase
  TNF receptor associated protein 1
  transaldolase 1
  transferrin
  transmembrane protein 120A
  triosephosphate isomerase 1
  tyrosine kinase 2
  ubiquitin conjugating enzyme E2 H
  ubiquitin fold modifier 1
  WD repeat domain 1
  WD repeat domain 82
  YKT6 v-SNARE homolog

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.