GSN, gelsolin

GSN, gelsolin

• The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (gelsolin, actin-depolymerizing factor, brevin, epididymis secretory sperm binding protein, ADF, AGEL,)
• NCBI Gene ID: 2934
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z4U6
  UNIPROT ID#>>P06396
  UNIPROT ID#>>A0A0A0MT01
  UNIPROT ID#>>A0A0A0MS51
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gelsolin interacts with:

• actin beta like 2
  actin related protein 1B
  actin related protein 2
  actin, beta
  AKT serine/threonine kinase 3
  anterior gradient 2, protein disulphide isomerase family member
  BAF chromatin remodeling complex subunit BCL7C
  BCAR1 scaffold protein, Cas family member
  CASP8 and FADD like apoptosis regulator
  CD2-associated protein
  chloride intracellular channel 5
  coronin, actin binding protein 1C
  cullin 7
  DEAD-box helicase 19B
  DISC1 scaffold protein
  dynactin 3
  dynein axonemal light intermediate chain 1
  eukaryotic translation initiation factor 3 subunit K
  F-box protein 25
  F-box protein 34
  F-box protein 40
  flotillin 1
  growth arrest specific 2 like 1
  heterogeneous nuclear ribonucleoprotein A1
  IQ motif containing GTPase activating protein 1
  itchy E3 ubiquitin protein ligase
  leucine rich repeat containing 39
  LIM domain and actin binding 1
  LIM domain and actin binding 1
  LIM domain kinase 2
  lymphocyte specific protein 1
  MAD2 mitotic arrest deficient-like 1
  MDM2 proto-oncogene
  microtubule associated protein 1S
  myosin heavy chain 9
  myosin IC
  myosin VI
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  nexilin F-actin binding protein
  N-methylpurine DNA glycosylase
  obscurin like cytoskeletal adaptor 1
  paxillin
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  phospholipase C gamma 1
  pleckstrin homology and RhoGEF domain containing G6
  pre-mRNA processing factor 8
  profilin 2
  proteasome 26S subunit, non-ATPase 4
  protein kinase C zeta
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 1 regulatory subunit 18
  protein phosphatase, Mg2+/Mn2+ dependent 1B
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 12
  PTEN induced kinase 1
  ring finger and CCCH-type domains 2
  RNA binding motif protein 18
  SAMM50 sorting and assembly machinery component
  SEC14 and spectrin domain containing 1
  serine/threonine kinase 39
  slingshot protein phosphatase 1
  small nuclear ribonucleoprotein U1 subunit 70
  SRC proto-oncogene, non-receptor tyrosine kinase
  succinate dehydrogenase complex iron sulfur subunit B
  synaptopodin
  target of myb1 like 1 membrane trafficking protein
  THO complex 1
  TPX2, microtubule-associated
  TRAF2 and NCK interacting kinase
  transcription factor CP2
  transmembrane p24 trafficking protein 10
  tropomodulin 1
  tropomodulin 2
  tropomodulin 3
  tropomodulin 3
  tropomyosin 1, alpha
  tropomyosin 4
  tumor protein p53
  ubiquitin conjugating enzyme E2 Q2
  vacuole membrane protein 1
  vasodilator stimulated phosphoprotein
  vinculin
  voltage dependent anion channel 1
  WASP like actin nucleation promoting factor
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.