PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

• Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]

• Gene Synonyms (phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, PI3-kinase p110 subunit alpha, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform, phosphoinositide-3-kinase, catalytic, alpha polypeptide, ptdIns-3-kinase subunit p110-alpha, serine/threonine protein kinase PIK3CA, CLAPO, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha,)
• NCBI Gene ID: 5290
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q4LE51
  UNIPROT ID#>>P42336
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha interacts with:

• adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  anaphase promoting complex subunit 7
  ArfGAP with dual PH domains 1
  ATP synthase inhibitory factor subunit 1
  brain expressed X-linked 1
  brain expressed X-linked 2
  BUB1, mitotic checkpoint serine/threonine kinase
  calcium/calmodulin dependent protein kinase IG
  cytohesin 2
  cytohesin 3
  derlin 1
  diacylglycerol kinase zeta
  DnaJ heat shock protein family (Hsp40) member B6
  dpy-30 histone methyltransferase complex regulatory subunit
  EARP complex and GARP complex interacting protein 1
  fibronectin leucine rich transmembrane protein 1
  GLIS family zinc finger 2
  hepatitis A virus cellular receptor 2
  histone deacetylase 6
  insulin receptor substrate 2
  insulin receptor substrate 4
  interleukin 20 receptor subunit alpha
  interleukin 24
  MANSC domain containing 1
  muscle RAS oncogene homolog
  NEDD4 like E3 ubiquitin protein ligase
  neuroligin 3
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 1
  protein kinase C alpha
  protein kinase C delta
  protein tyrosine phosphatase non-receptor type 11
  PSMC3 interacting protein
  PTTG1 regulator of sister chromatid separation, securin
  Rac family small GTPase 1
  Rap guanine nucleotide exchange factor 5
  RAS guanyl releasing protein 3
  RASD family member 2
  RELA proto-oncogene, NF-kB subunit
  Rho guanine nucleotide exchange factor 1
  ribonucleotide reductase regulatory subunit M2
  ribosomal protein S20
  ribosomal protein S27
  ribosomal protein S3
  ribosomal protein S6 kinase B1
  ring finger protein 19B
  Sad1 and UNC84 domain containing 2
  sequestosome 1
  serine/threonine kinase 11
  serum/glucocorticoid regulated kinase 1
  SH3 domain containing kinase binding protein 1
  signal transducer and activator of transcription 1
  sorting nexin 9
  tetraspanin 14
  thyroid hormone responsive
  TNF receptor associated factor 6
  TNF receptor superfamily member 1A
  TNF superfamily member 13
  toll like receptor adaptor molecule 1
  transmembrane protein 52B
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  ubiquitin recognition factor in ER associated degradation 1
  upstream binding transcription factor
  uridine monophosphate synthetase
  valyl-tRNA synthetase 2, mitochondrial
  vir like m6A methyltransferase associated
  WD repeat domain 5
  zinc finger DHHC-type containing 1
  zinc finger DHHC-type palmitoyltransferase 18
  zinc finger DHHC-type palmitoyltransferase 23

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.