PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

• Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]

• Gene Synonyms (phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-phosphatidylinositol 3-kinase, PI3-kinase subunit gamma, phosphatidylinositol 3 kinase gamma, p110 gamma, phosphatidylinositol 3-kinase catalytic 110-kD gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphoinositide-3-kinase gamma catalytic subunit, ptdIns-3-kinase subunit gamma, ptdIns-3-kinase subunit p110-gamma, serine/threonine protein kinase PIK3CG, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K,)
• NCBI Gene ID: 5294
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P48736
  UNIPROT ID#>>A8K9G9
  UNIPROT ID#>>A0A024R720
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma interacts with:

• aminopeptidase puromycin sensitive
  beclin 1
  citron rho-interacting serine/threonine kinase
  eEF1A lysine and N-terminal methyltransferase
  G protein subunit gamma 2
  GABA type A receptor associated protein like 1
  linker for activation of T cells
  mitogen-activated protein kinase kinase 5
  N-acetylglucosamine kinase
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 5
  phosphoinositide-3-kinase regulatory subunit 6
  protein arginine methyltransferase 7
  protein kinase AMP-activated catalytic subunit alpha 2
  protein tyrosine phosphatase 4A3
  protein tyrosine phosphatase non-receptor type 11
  retinoic acid receptor alpha
  SEC14 like lipid binding 2
  SET nuclear proto-oncogene
  sphingomyelin phosphodiesterase 2
  sphingosine kinase 1
  spleen associated tyrosine kinase
  tropomyosin 2
  ubiquitin specific peptidase 45
  utrophin
  zinc finger protein 282

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.