BRF1, BRF1 RNA polymerase III transcription initiation factor subunit

BRF1, BRF1 RNA polymerase III transcription initiation factor subunit

• This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]

• Gene Synonyms (transcription factor IIIB 90 kDa subunit, B - related factor 1, BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB, BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit, TATA box binding protein (TBP)-associated factor 3C, TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2, TBP - associated factor, RNA polymerase III, 90kD, epididymis secretory sperm binding protein Li 76p, general transcription factor IIIB, 90kD subunit, BRF, BRF-1, CFDS, GTF3B, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF,)
• NCBI Gene ID: 2972
• Species: Homo sapiens (Human)
• UNIPROT ID#>>V9HVY2
  UNIPROT ID#>>Q92994
  UNIPROT ID#>>A0A024R6P8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

BRF1 RNA polymerase III transcription initiation factor subunit interacts with:

• agrin
  anti-silencing function 1A histone chaperone
  dermcidin
  dystrobrevin binding protein 1
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation elongation factor 1 alpha 1
  family with sequence similarity 83 member H
  general transcription factor IIIC subunit 3
  general transcription factor IIIC subunit 4
  general transcription factor IIIC subunit 5
  G-protein signalling modulator 1 (AGS3-like, C. elegans)
  H1.2 linker histone, cluster member
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 4
  heat shock protein family H (Hsp110) member 1
  heterogeneous nuclear ribonucleoprotein U
  histone cell cycle regulator
  ITPR interacting domain containing 2
  keratin 17
  leucine zipper protein 1
  LRR binding FLII interacting protein 1
  mitotic spindle positioning
  NOP2 nucleolar protein
  nucleolar and coiled-body phosphoprotein 1
  nucleolin
  peroxidasin
  poly(rC) binding protein 2
  polypyrimidine tract binding protein 1
  POTE ankyrin domain family member I
  pre-mRNA processing factor 4
  proteasome 26S subunit, ATPase 1
  protein phosphatase 1 regulatory subunit 12A
  protein phosphatase 1 regulatory subunit 9B
  pterin-4 alpha-carbinolamine dehydratase 2
  PTPRF interacting protein alpha 1
  RAB5C, member RAS oncogene family
  ras homolog family member U
  RB transcriptional corepressor 1
  RB transcriptional corepressor like 1
  RB transcriptional corepressor like 2
  retinoic acid induced 14
  ring finger protein, LIM domain interacting
  RNA polymerase III subunit E
  RNA polymerase III subunit F
  S100 calcium binding protein A8
  SERPINE1 mRNA binding protein 1
  small ubiquitin like modifier 2
  staphylococcal nuclease and tudor domain containing 1
  TATA-box binding protein
  transcription factor 20
  tripartite motif containing 27
  tumor protein p53
  ubinuclein 1
  ubiquitin C
  ubiquitin specific peptidase 28
  von Hippel-Lindau binding protein 1
  VPS50 subunit of EARP/GARPII complex
  zinc finger protein 649

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.