ITK, IL2 inducible T cell kinase

ITK, IL2 inducible T cell kinase

• This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (EMT, LPFS1, LYK, PSCTK2, tyrosine-protein kinase ITK/TSK, IL-2-inducible T-cell kinase, T-cell-specific kinase, homolog of mouse T-cell itk/tsk, interleukin-2-inducible T-cell kinase, kinase EMT, tyrosine-protein kinase LYK,)
• NCBI Gene ID: 3702
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q08881
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

IL2 inducible T cell kinase interacts with:

• B cell linker
  cell division cycle 37, HSP90 cochaperone
  elongin B
  glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
  IL2 inducible T cell kinase
  inhibitor of Bruton tyrosine kinase
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  karyopherin subunit alpha 2
  KH RNA binding domain containing, signal transduction associated 1
  LCK proto-oncogene, Src family tyrosine kinase
  linker for activation of T cells
  lymphocyte cytosolic protein 2
  myelin basic protein
  NOP2/Sun RNA methyltransferase 6
  peptidylprolyl isomerase A
  phosphoinositide-3-kinase regulatory subunit 1
  phospholipase C gamma 1
  phospholipase C gamma 2
  SH2 domain containing 2A
  SMAD family member 4
  SMAD specific E3 ubiquitin protein ligase 1
  small proline rich protein 2A
  SRC proto-oncogene, non-receptor tyrosine kinase
  suppressor of cytokine signaling 1
  transforming growth factor beta receptor 1
  WASP actin nucleation promoting factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.