JAK3, Janus kinase 3

JAK3, Janus kinase 3

• The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

• Gene Synonyms (JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK, tyrosine-protein kinase JAK3, Janus kinase 3 (a protein tyrosine kinase, leukocyte), leukocyte Janus kinase,)
• NCBI Gene ID: 3718
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P52333
  UNIPROT ID#>>A0A024R7M7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Janus kinase 3 interacts with:

• BAG cochaperone 2
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 8
  C-X-C motif chemokine receptor 4
  cyclin L2
  DEAH-box helicase 16
  gem nuclear organelle associated protein 6
  G-patch domain containing 8
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  insulin receptor substrate 2
  Janus kinase 3
  KH RNA binding domain containing, signal transduction associated 1
  KIT proto-oncogene, receptor tyrosine kinase
  LCK proto-oncogene, Src family tyrosine kinase
  leptin receptor
  ligand of numb-protein X 1
  LysM domain containing 2
  MAGE family member D2
  metal response element binding transcription factor 2
  mitochondrial ribosomal protein L23
  neuropeptide Y receptor Y4
  nicotinamide phosphoribosyltransferase
  N-myc and STAT interactor
  nucleosome assembly protein 1 like 1
  nucleosome assembly protein 1 like 4
  phosphoinositide-3-kinase regulatory subunit 1
  protein arginine methyltransferase 5
  protein kinase AMP-activated non-catalytic subunit beta 1
  protein kinase, DNA-activated, catalytic subunit
  protein tyrosine phosphatase non-receptor type 2
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type C
  RAB11 family interacting protein 2
  RAB11A, member RAS oncogene family
  RNA binding protein with serine rich domain 1
  serine palmitoyltransferase long chain base subunit 1
  serine/arginine repetitive matrix 2
  SH2 domain containing adaptor protein B
  SH2B adaptor protein 2
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  signal transducer and activator of transcription 6
  signal transducing adaptor molecule
  signal transducing adaptor molecule 2
  somatostatin receptor 4
  STIP1 homology and U-box containing protein 1
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 3
  suppressor of cytokine signaling 5
  TATA-box binding protein associated factor 1
  t-complex 1
  TGFB1-induced anti-apoptotic factor 1
  transportin 3
  tubulin alpha 4a
  tubulin beta 1 class VI
  tyrosine kinase 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin protein ligase E3 component n-recognin 5
  villin 1
  WD repeat domain 46

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.