LDHA, lactate dehydrogenase A

LDHA, lactate dehydrogenase A

• The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

• Gene Synonyms (GSD11, HEL-S-133P, LDHM, PIG19, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, cell proliferation-inducing gene 19 protein, epididymis secretory sperm binding protein Li 133P, lactate dehydrogenase M, proliferation-inducing gene 19, renal carcinoma antigen NY-REN-59,)
• NCBI Gene ID: 3939
• Species: Homo sapiens (Human)
• UNIPROT ID#>>V9HWB9
  UNIPROT ID#>>P00338
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lactate dehydrogenase A interacts with:

• 3-hydroxyisobutyrate dehydrogenase
  5'-3' exoribonuclease 1
  AAR2 splicing factor
  ACD shelterin complex subunit and telomerase recruitment factor
  acetyl-CoA acyltransferase 2
  activating transcription factor 6
  activator of HSP90 ATPase activity 1
  agrin
  aldehyde dehydrogenase 4 family member A1
  aminopeptidase puromycin sensitive
  ankyrin repeat and SOCS box containing 9
  anterior gradient 2, protein disulphide isomerase family member
  ATP binding cassette subfamily C member 9
  autophagy related 16 like 1
  basic leucine zipper and W2 domains 1
  BRCA2 and CDKN1A interacting protein
  BRO1 domain and CAAX motif containing
  carnosine dipeptidase 2
  cell division cycle 73
  centrosomal protein 290
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 6B
  chromosome 11 open reading frame 58
  coiled-coil domain containing 8
  cullin 3
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cytoskeleton associated protein 5
  destrin, actin depolymerizing factor
  DNA ligase 4
  dynamin 1 like
  dynein light chain LC8-type 1
  EEF1A lysine methyltransferase 3
  elongation factor Tu GTP binding domain containing 2
  ERCC excision repair 6 like, spindle assembly checkpoint helicase
  Fas associated factor 1
  F-box protein 6
  FTO alpha-ketoglutarate dependent dioxygenase
  fumarylacetoacetate hydrolase domain containing 1
  glutathione S-transferase omega 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  HNF1 homeobox A
  interferon induced protein 44 like
  ISG15 ubiquitin like modifier
  kynureninase
  lactate dehydrogenase A
  lactate dehydrogenase A like 6B
  lactate dehydrogenase B
  lactate dehydrogenase C
  lysine acetyltransferase 5
  macrophage migration inhibitory factor
  malate dehydrogenase 1
  methyltransferase like 14
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 10
  mitogen-activated protein kinase 13
  MYC proto-oncogene, bHLH transcription factor
  N-acetylglucosamine kinase
  neurotrophic receptor tyrosine kinase 1
  nitrilase family member 2
  NME/NM23 nucleoside diphosphate kinase 2
  NME1-NME2 readthrough
  N-myc downstream regulated 1
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  obscurin like cytoskeletal adaptor 1
  palmitoyl-protein thioesterase 1
  pantothenate kinase 4
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  PAX interacting protein 1
  peptidase D
  peptidylprolyl isomerase A
  peroxiredoxin 2
  peroxiredoxin 5
  phosphoenolpyruvate carboxykinase 1
  phosphoethanolamine/phosphocholine phosphatase 1
  phosphoglucomutase 1
  phosphogluconate dehydrogenase
  phosphoglycerate kinase 1
  PIH1 domain containing 1
  platelet activating factor acetylhydrolase 1b catalytic subunit 3
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  prohibitin
  proliferating cell nuclear antigen
  prolylcarboxypeptidase
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, ATPase 2
  protection of telomeres 1
  protein kinase C substrate 80K-H
  protein phosphatase methylesterase 1
  protein phosphatase, Mg2+/Mn2+ dependent 1K
  protein tyrosine phosphatase receptor type F
  PTEN induced kinase 1
  pyruvate dehydrogenase E1 subunit alpha 1
  pyruvate kinase M1/2
  RAB1A, member RAS oncogene family
  RAB1B, member RAS oncogene family
  RAB5A, member RAS oncogene family
  RAB5C, member RAS oncogene family
  RAB6B, member RAS oncogene family
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  replication protein A1
  replication protein A2
  replication protein A3
  ribosomal protein S6 kinase A1
  ring finger protein 2
  RIO kinase 1
  secreted protein acidic and cysteine rich
  sepiapterin reductase
  sequestosome 1
  SKI proto-oncogene
  snail family transcriptional repressor 1
  sorbitol dehydrogenase
  spermine synthase
  staufen double-stranded RNA binding protein 1
  sterol O-acyltransferase 1
  STIP1 homology and U-box containing protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  succinate dehydrogenase complex iron sulfur subunit B
  succinate-CoA ligase GDP-forming subunit beta
  superoxide dismutase 1
  TAR DNA binding protein
  telomeric repeat binding factor 1
  TERF1 interacting nuclear factor 2
  testis expressed 101
  tet methylcytosine dioxygenase 2
  TNFAIP3 interacting protein 2
  transaldolase 1
  transcription elongation factor A1
  transcription factor CP2
  transketolase
  triosephosphate isomerase 1
  tripartite motif containing 25
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 14
  unk zinc finger
  UPF2 regulator of nonsense mediated mRNA decay
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  WD repeat domain 1
  Yes1 associated transcriptional regulator
  zinc finger CCCH-type containing 7A
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.