NFKB1, nuclear factor kappa B subunit 1

NFKB1, nuclear factor kappa B subunit 1

• This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]

• Gene Synonyms (CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1, NF-kappaB, NF-kappabeta, NFKB-p105, NFKB-p50, NFkappaB, nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, nuclear factor NF-kappa-B p50 subunit, nuclear factor kappa-B DNA binding subunit, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,)
• NCBI Gene ID: 4790
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RDJ4
  UNIPROT ID#>>P19838
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear factor kappa B subunit 1 interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  aurora kinase A
  aurora kinase B
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BICD cargo adaptor 2
  BRMS1 transcriptional repressor and anoikis regulator
  BTG3 associated nuclear protein
  CASP8 and FADD like apoptosis regulator
  CCR4-NOT transcription complex subunit 11
  CCR4-NOT transcription complex subunit 2
  CCR4-NOT transcription complex subunit 6
  CCR4-NOT transcription complex subunit 6 like
  CCR4-NOT transcription complex subunit 7
  cellular communication network factor 3
  checkpoint kinase 2
  CLN6 transmembrane ER protein
  coactivator associated arginine methyltransferase 1
  COMM domain containing 10
  COMM domain containing 2
  COMM domain containing 3
  COMM domain containing 4
  COMM domain containing 5
  COMM domain containing 6
  COMM domain containing 8
  COMM domain containing 9
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COPI coat complex subunit beta 2
  copper metabolism domain containing 1
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  defective in cullin neddylation 1 domain containing 1
  DNA methyltransferase 3 like
  dolichyl-phosphate mannosyltransferase subunit 1, catalytic
  double PHD fingers 1
  double PHD fingers 2
  double PHD fingers 3
  ECSIT signaling integrator
  elongin B
  eukaryotic translation initiation factor 3 subunit I
  exportin 1
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  G3BP stress granule assembly factor 2
  glutaminyl-peptide cyclotransferase like
  glutathione peroxidase 8 (putative)
  HIG1 hypoxia inducible domain family member 1A
  high mobility group AT-hook 2
  histone deacetylase 3
  histone deacetylase 4
  histone deacetylase 5
  hook microtubule tethering protein 1
  hook microtubule tethering protein 3
  hypoxia inducible factor 1 subunit alpha inhibitor
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  integrin subunit beta 3 binding protein
  interferon regulatory factor 9
  IQ motif containing GTPase activating protein 3
  leucine rich pentatricopeptide repeat containing
  lysine acetyltransferase 5
  mannosyl-oligosaccharide glucosidase
  MAX dimerization protein 3
  membrane palmitoylated protein 6
  mitochondrial poly(A) polymerase
  myotrophin
  myotubularin related protein 2
  neutrophil cytosolic factor 1
  NFKB inhibitor alpha
  NFKB inhibitor beta
  NFKB inhibitor delta
  NFKB inhibitor epsilon
  NFKB inhibitor zeta
  NFKB repressing factor
  notch receptor 1
  nuclear factor kappa B subunit 1
  nuclear factor kappa B subunit 2
  nuclear factor related to kappaB binding protein
  nuclear receptor coactivator 1
  nuclear receptor coactivator 3
  nuclear receptor coactivator 6
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  nuclear transcription factor Y subunit gamma
  nucleolar protein 9
  peptidyl arginine deiminase 3
  peroxisome proliferator activated receptor gamma
  PHD finger protein 10
  phospholipase D family member 3
  phosphoribosyl pyrophosphate synthetase 1 like 1
  PML nuclear body scaffold
  PPARG coactivator 1 alpha
  programmed cell death 11
  programmed cell death 6
  proline, glutamate and leucine rich protein 1
  proteasome 20S subunit alpha 4
  proteasome 26S subunit, non-ATPase 10
  protein kinase cAMP-activated catalytic subunit alpha
  protein phosphatase 1 regulatory subunit 13 like
  protein phosphatase 4 catalytic subunit
  protein phosphatase methylesterase 1
  pterin-4 alpha-carbinolamine dehydratase 1
  receptor interacting serine/threonine kinase 1
  regulator of G protein signaling 14
  REL proto-oncogene, NF-kB subunit
  RELA proto-oncogene, NF-kB subunit
  RELB proto-oncogene, NF-kB subunit
  remodeling and spacing factor 1
  retinoid X receptor alpha
  ribosomal protein S10
  ribosomal protein S15
  ribosomal protein S3
  ribosomal protein S6 kinase A5
  ring finger protein 123
  RNA polymerase II subunit A
  RuvB like AAA ATPase 2
  saccharopine dehydrogenase (putative)
  SEC61 translocon subunit alpha 1
  serum response factor
  signal peptide peptidase like 2A
  signal sequence receptor subunit 1
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 6
  Sp1 transcription factor
  sperm associated antigen 9
  Spi-1 proto-oncogene
  splicing factor 1
  splicing factor 3b subunit 6
  SRA stem-loop interacting RNA binding protein
  suppressor of cytokine signaling 3
  SUZ12 polycomb repressive complex 2 subunit
  TANK binding kinase 1
  tankyrase 1 binding protein 1
  TEA domain transcription factor 4
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  thioredoxin
  thyroid hormone receptor interactor 4
  TNF alpha induced protein 3
  TNF superfamily member 11
  TNFAIP3 interacting protein 1
  TNFAIP3 interacting protein 2
  TNFAIP3 interacting protein 3
  trans-2,3-enoyl-CoA reductase
  transcription factor AP-2 alpha
  tripartite motif containing 14
  tumor protein p53 binding protein 1
  tumor protein p53 binding protein 2
  tumor protein p63
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin conjugating enzyme E2 D3
  ubiquitin specific peptidase 9 X-linked
  unc-5 family C-terminal like
  valosin containing protein
  vir like m6A methyltransferase associated
  vitamin D receptor
  VPS26, retromer complex component A
  WD repeat domain 6
  X-ray repair cross complementing 4
  YY1 transcription factor
  ZFP36 ring finger protein
  zinc finger and BTB domain containing 9
  zinc fingers and homeoboxes 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.