NFYA, nuclear transcription factor Y subunit alpha

NFYA, nuclear transcription factor Y subunit alpha

• The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CBF-A, CBF-B, HAP2, NF-YA, nuclear transcription factor Y subunit alpha, CAAT-box DNA binding protein subunit A, CCAAT-binding transcription factor subunit B, HAP2 CCAAT-binding protein, Transcription factor NF-Y, A subunit, nuclear transcription factor Y subunit A, nuclear transcription factor Y, alpha,)
• NCBI Gene ID: 4800
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RD22
  UNIPROT ID#>>P23511
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear transcription factor Y subunit alpha interacts with:

• activating transcription factor 6
  amyloid beta precursor protein binding protein 2
  ataxin 1
  BTG3 associated nuclear protein
  charged multivesicular body protein 4A
  FTO alpha-ketoglutarate dependent dioxygenase
  glutamine rich 1
  immunity related GTPase Q
  LUC7 like 2, pre-mRNA splicing factor
  nuclear RNA export factor 1
  nuclear transcription factor Y subunit alpha
  nuclear transcription factor Y subunit beta
  nuclear transcription factor Y subunit gamma
  nuclear transcription factor-Y gamma
  pogo transposable element derived with ZNF domain
  poly(A) polymerase gamma
  POU class 2 homeobox 1
  POU class 3 homeobox 2
  PWP1 homolog, endonuclein
  ribosomal protein S6 kinase A6
  serine and arginine rich splicing factor 1
  serine hydroxymethyltransferase 2
  serum response factor
  Sp1 transcription factor
  Spi-1 proto-oncogene
  sterol regulatory element binding transcription factor 2
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 12
  TATA-box binding protein associated factor 6
  testin LIM domain protein
  toll like receptor 9
  TRPM8 channel associated factor 1
  tumor protein p53
  tumor protein p63
  ubiquitin conjugating enzyme E2 D2
  ubiquitin like 5
  UDP-N-acetylglucosamine pyrophosphorylase 1
  upstream transcription factor 1
  upstream transcription factor 2, c-fos interacting
  vascular endothelial zinc finger 1
  zinc finger CCCH-type containing 10
  zinc fingers and homeoboxes 1
  zinc fingers and homeoboxes 2
  zinc fingers and homeoboxes 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.