ATP4A, ATPase H+/K+ transporting subunit alpha

ATP4A, ATPase H+/K+ transporting subunit alpha

• The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

• Gene Synonyms (potassium-transporting ATPase alpha chain 1, ATPase H+/K+ transporting alpha subunit, ATPase, H+/K+ exchanging, alpha polypeptide, ATPase, H+/K+ transporting, alpha polypeptide, epididymis secretory sperm binding protein, gastric H+/K+ ATPase alpha subunit, gastric H,K-ATPase catalytic subunit, gastric hydrogen-potassium ATPase, proton pump, ATP6A,)
• NCBI Gene ID: 495
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P20648
  UNIPROT ID#>>Q658V6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ATPase H+/K+ transporting subunit alpha interacts with:

• acyl-CoA synthetase long chain family member 1
  ADP ribosylation factor like GTPase 6 interacting protein 5
  AHNAK nucleoprotein
  amine oxidase copper containing 3
  anterior gradient 2, protein disulphide isomerase family member
  armadillo repeat containing 1
  ATPase H+ transporting V1 subunit A
  ATPase H+/K+ transporting subunit alpha
  ATPase H+/K+ transporting subunit beta
  B cell receptor associated protein 31
  basigin (Ok blood group)
  carbonic anhydrase 9
  carboxypeptidase D
  catenin delta 1
  caveolin 1
  CD163 molecule
  CDC like kinase 1
  cell division cycle associated 8
  clathrin heavy chain
  cobalamin binding intrinsic factor
  deoxyguanosine kinase
  dynein axonemal assembly factor 2
  endoplasmic reticulum oxidoreductase 1 beta
  epoxide hydrolase 1
  FAM3 metabolism regulating signaling molecule B
  FAM3 metabolism regulating signaling molecule C
  Fas associated factor family member 2
  G protein subunit alpha i1
  G protein subunit alpha i2
  G protein subunit alpha q
  G protein subunit gamma 2
  galectin 3 binding protein
  glucosidase II alpha subunit
  HCLS1 associated protein X-1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HEXIM P-TEFb complex subunit 1
  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
  kallikrein related peptidase 8
  lanosterol synthase
  lectin, mannose binding 2
  leucine rich repeat containing G protein-coupled receptor 4
  lipase C, hepatic type
  lipase F, gastric type
  mal, T cell differentiation protein 2
  mannose receptor C-type 1
  mannose-6-phosphate receptor, cation dependent
  NSF attachment protein alpha
  nuclear FMR1 interacting protein 1
  potassium voltage-gated channel subfamily E regulatory subunit 2
  potassium voltage-gated channel subfamily Q member 1
  progastricsin
  prostate stem cell antigen
  protein tyrosine phosphatase non-receptor type 1
  RAB10, member RAS oncogene family
  RAB11A, member RAS oncogene family
  RAB11B, member RAS oncogene family
  RAB1A, member RAS oncogene family
  RAB25, member RAS oncogene family
  RAB5C, member RAS oncogene family
  ribosomal RNA processing 7 homolog A
  scavenger receptor class B member 2
  SEC22 homolog B, vesicle trafficking protein
  secretory carrier membrane protein 2
  secretory carrier membrane protein 3
  solute carrier family 12 member 2
  solute carrier family 26 member 9
  synaptogyrin 2
  synaptophysin like 1
  syntaxin 12
  syntaxin 3
  syntaxin 7
  transferrin receptor 2
  transmembrane protein 41B
  transmembrane protein adipocyte associated 1
  UBX domain protein 8
  vesicle amine transport 1
  vesicle associated membrane protein 1
  vesicle associated membrane protein 2
  vesicle associated membrane protein 3
  vesicle associated membrane protein 5
  vesicle associated membrane protein 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.