PMS1, PMS1 homolog 1, mismatch repair system component

PMS1, PMS1 homolog 1, mismatch repair system component

• This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]

• Gene Synonyms (PMS1 protein homolog 1, DNA mismatch repair protein PMS1, PMS1 postmeiotic segregation increased 1, human homolog of yeast mutL, mismatch repair gene PMSL1, rhabdomyosarcoma antigen MU-RMS-40.10B, rhabdomyosarcoma antigen MU-RMS-40.10E, HNPCC3, MLH2, PMSL1, hPMS1,)
• NCBI Gene ID: 5378
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E9PC40
  UNIPROT ID#>>Q3BDU3
  UNIPROT ID#>>B7ZAA0
  UNIPROT ID#>>I6L9H5
  UNIPROT ID#>>Q5XG96
  UNIPROT ID#>>P54277
  UNIPROT ID#>>B4DIH7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

PMS1 homolog 1, mismatch repair system component interacts with:

• AHNAK nucleoprotein
  A-kinase anchoring protein 9
  Bardet-Biedl syndrome 7
  BRCA1 interacting protein C-terminal helicase 1
  cullin 1
  cullin 3
  DNA helicase B
  DNA topoisomerase I
  dynein light chain Tctex-type 1
  dynein light chain Tctex-type 3
  exonuclease 1
  FANCD2 and FANCI associated nuclease 1
  glycogen phosphorylase B
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  importin 9
  minichromosome maintenance 9 homologous recombination repair factor
  MMS19 homolog, cytosolic iron-sulfur assembly component
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  pleckstrin and Sec7 domain containing 2
  PMS1 homolog 1, mismatch repair system component
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 3
  protein phosphatase 2 scaffold subunit Aalpha
  PTTG1 regulator of sister chromatid separation, securin
  RAN binding protein 9
  Ran GTPase activating protein 1
  replication factor C subunit 1
  replication factor C subunit 2
  replication factor C subunit 4
  REV3 like, DNA directed polymerase zeta catalytic subunit
  ring finger protein 123
  ring finger protein 20
  RNA polymerase I and III subunit C
  SET binding factor 1
  SET binding factor 2
  sorting nexin family member 21
  structural maintenance of chromosomes 3
  ubiquitin associated protein 2 like
  ubiquitin C
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin specific peptidase 13
  ubiquitin specific peptidase 5
  ubiquitin specific peptidase 9 Y-linked
  vesicle associated membrane protein 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.