POLD1, DNA polymerase delta 1, catalytic subunit

POLD1, DNA polymerase delta 1, catalytic subunit

• This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]

• Gene Synonyms (DNA polymerase delta catalytic subunit, 3'-5' exodeoxyribonuclease, CDC2 homolog, DNA polymerase subunit delta p125, polymerase (DNA directed), delta 1, catalytic subunit 125kDa, polymerase (DNA) delta 1, catalytic subunit, CDC2, CRCS10, MDPL, POLD,)
• NCBI Gene ID: 5424
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R4F4
  UNIPROT ID#>>Q308M6
  UNIPROT ID#>>M0R2B7
  UNIPROT ID#>>P28340
  UNIPROT ID#>>Q59FA0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DNA polymerase delta 1, catalytic subunit interacts with:

• ADAMTS like 4
  adaptor related protein complex 3 subunit beta 1
  ariadne RBR E3 ubiquitin protein ligase 1
  autophagy related 16 like 1
  catenin beta like 1
  centrosomal protein 126
  centrosomal protein 192
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 8
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  CREB regulated transcription coactivator 3
  cullin 1
  cullin 3
  cullin 4B
  cytosolic iron-sulfur assembly component 1
  cytosolic iron-sulfur assembly component 2B
  DEAD-box helicase 20
  DNA polymerase delta 1, catalytic subunit
  DNA polymerase delta 2, accessory subunit
  DNA polymerase delta 3, accessory subunit
  DNA polymerase delta 4, accessory subunit
  DNA polymerase kappa
  DnaJ heat shock protein family (Hsp40) member A2
  egl-9 family hypoxia inducible factor 3
  ELL associated factor 1
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 2 alpha kinase 1
  exportin 1
  GAR1 ribonucleoprotein
  GINS complex subunit 4
  glucose-fructose oxidoreductase domain containing 1
  heat shock protein family H (Hsp110) member 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  matrin 3
  mediator complex subunit 23
  mediator of DNA damage checkpoint 1
  methyltransferase like 3
  microcephalin 1
  mitogen-activated protein kinase 6
  MMS19 homolog, cytosolic iron-sulfur assembly component
  myotubularin related protein 4
  non-SMC condensin I complex subunit G
  nuclear assembly factor 1 ribonucleoprotein
  nuclear distribution C, dynein complex regulator
  nuclear receptor subfamily 2 group C member 2
  nucleolar and coiled-body phosphoprotein 1
  obscurin like cytoskeletal adaptor 1
  p53-induced death domain protein 1
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  pleckstrin homology domain containing A4
  proliferating cell nuclear antigen
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 regulatory subunit B'gamma
  protein tyrosine phosphatase 4A3
  purine rich element binding protein B
  RAD51 recombinase
  RB transcriptional corepressor 1
  replication protein A1
  replication protein A2
  replication protein A3
  Rho GTPase activating protein 25
  ribonuclease/angiogenin inhibitor 1
  ribophorin I
  ring finger protein 126
  ring finger protein 2
  RIO kinase 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 14
  RuvB like AAA ATPase 2
  SNW domain containing 1
  SprT-like N-terminal domain
  staufen double-stranded RNA binding protein 1
  TATA-box binding protein associated factor 2
  TBC1 domain family member 2
  TBC1 domain family member 4
  t-complex 1
  telomeric repeat binding factor 2
  TERF2 interacting protein
  three prime repair exonuclease 2
  thyroid hormone receptor interactor 10
  tripartite motif containing 28
  tRNA splicing endonuclease subunit 2
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  ubiquitin specific peptidase 43
  unc-93 homolog B1, TLR signaling regulator
  UPF1 RNA helicase and ATPase
  UPF2 regulator of nonsense mediated mRNA decay
  WASP family member 2
  WD repeat domain 44
  WRN helicase interacting protein 1
  X-ray repair cross complementing 1
  X-ray repair cross complementing 5
  yippee like 3
  YOD1 deubiquitinase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.