PPAT, phosphoribosyl pyrophosphate amidotransferase

PPAT, phosphoribosyl pyrophosphate amidotransferase

• The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]

• Gene Synonyms (amidophosphoribosyltransferase, glutamine PRPP amidotransferase, glutamine phosphoribosylpyrophosphatate amidotransferase, glutamine phosphoribosylpyrophosphate amidotransferase, ATASE, GPAT, PRAT,)
• NCBI Gene ID: 5471
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q06203
  UNIPROT ID#>>A8K4H7
  UNIPROT ID#>>Q59G63
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphoribosyl pyrophosphate amidotransferase interacts with:

• aminopeptidase like 1
  ataxin 1
  CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
  coactivator associated arginine methyltransferase 1
  cytosolic iron-sulfur assembly component 1
  cytosolic iron-sulfur assembly component 2B
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 114 member A1
  F-box and WD repeat domain containing 11
  histone deacetylase 3
  MMS19 homolog, cytosolic iron-sulfur assembly component
  nudix hydrolase 5
  parvin alpha
  phosphoribosyl pyrophosphate amidotransferase
  phosphoribosyl pyrophosphate synthetase 1
  phosphoribosyl pyrophosphate synthetase 2
  pleckstrin homology domain containing A4
  protein phosphatase 2 catalytic subunit alpha
  RAN binding protein 3
  Ras suppressor protein 1
  RecQ like helicase 4
  Ro60, Y RNA binding protein
  selenoprotein I
  serine hydroxymethyltransferase 1
  SMAD specific E3 ubiquitin protein ligase 1
  sorting nexin 2
  staufen double-stranded RNA binding protein 1
  thymidylate synthetase
  ubiquitin like modifier activating enzyme 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.