TAF4, TATA-box binding protein associated factor 4

TAF4, TATA-box binding protein associated factor 4

• Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transcription initiation factor TFIID subunit 4, RNA polymerase II TBP-associated factor subunit C, TAF(II)130, TAF(II)135, TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa, TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD, TAFII-130, TAFII-135, TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit, transcription initiation factor TFIID 135 kD subunit, transcription initiation factor TFIID 135 kDa subunit, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135,)
• NCBI Gene ID: 6874
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00268
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TATA-box binding protein associated factor 4 interacts with:

• activating transcription factor 7
  anaphase promoting complex subunit 1
  anaphase promoting complex subunit 13
  anaphase promoting complex subunit 7
  anoctamin 7
  cell division cycle 16
  cell division cycle 23
  chromobox 3
  chromobox 5
  F-box protein 38
  F-box protein 6
  H3 clustered histone 1
  H3 clustered histone 6
  H3.4 histone
  H4 clustered histone 1
  kinesin associated protein 3
  listerin E3 ubiquitin protein ligase 1
  mediator complex subunit 26
  nuclear receptor subfamily 2 group C member 2
  nucleoporin 50
  polynucleotide kinase 3'-phosphatase
  septin 6
  splicing factor 3b subunit 3
  SPT3 homolog, SAGA and STAGA complex component
  SRY-box transcription factor 6
  TATA-box binding protein
  TATA-box binding protein associated factor 1 like
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 12
  TATA-box binding protein associated factor 13
  TATA-box binding protein associated factor 3
  TATA-box binding protein associated factor 4
  TATA-box binding protein associated factor 5
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 7
  TATA-box binding protein associated factor 7 like
  TATA-box binding protein associated factor 8
  TATA-box binding protein associated factor 9
  TATA-box binding protein associated factor 9b
  TATA-box binding protein like 1
  transcription factor 12
  transformation/transcription domain associated protein
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.