VCAN, versican

VCAN, versican

• This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

• Gene Synonyms (versican core protein, chondroitin sulfate proteoglycan core protein 2, glial hyaluronate-binding protein, large fibroblast proteoglycan, versican proteoglycan, CSPG2, ERVR, GHAP, PG-M, WGN, WGN1,)
• NCBI Gene ID: 1462
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RAP3
  UNIPROT ID#>>Q6MZK8
  UNIPROT ID#>>A0A024RAQ9
  UNIPROT ID#>>Q59FG9
  UNIPROT ID#>>A0A024RAL1
  UNIPROT ID#>>Q86W61
  UNIPROT ID#>>P13611
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

versican interacts with:

• ADAM metallopeptidase with thrombospondin type 1 motif 1
  brevican
  C-C motif chemokine ligand 2
  C-C motif chemokine ligand 20
  C-C motif chemokine ligand 21
  C-C motif chemokine ligand 5
  C-C motif chemokine ligand 8
  C-X-C motif chemokine ligand 10
  C-X-C motif chemokine ligand 12
  fibrillin 1
  fibulin 1
  fibulin 2
  heat shock transcription factor family, X-linked 1
  hyaluronan and proteoglycan link protein 1
  integrin subunit alpha 4
  integrin subunit beta 1
  phospholipase A2 group IIA
  platelet factor 4
  protein tyrosine phosphatase receptor type F
  pyrin and HIN domain family member 1
  RAB19, member RAS oncogene family
  selectin L
  selectin P
  selectin P ligand
  spindle apparatus coiled-coil protein 1
  TAFA chemokine like family member 4
  tenascin R
  versican
  X-C motif chemokine ligand 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.