NKX2-5, NK2 homeobox 5

NKX2-5, NK2 homeobox 5

• This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

• Gene Synonyms (homeobox protein Nkx-2.5, NK2 transcription factor related, locus 5, NKX 2-5, cardiac-specific homeobox 1, homeobox protein CSX, homeobox protein NK-2 homolog E, homeobox protein NKX 2-5, tinman paralog, CHNG5, CSX, CSX1, HLHS2, NKX2.5, NKX2E, NKX4-1, VSD3,)
• NCBI Gene ID: 1482
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z3K2
  UNIPROT ID#>>P52952
  UNIPROT ID#>>E5RH49
  UNIPROT ID#>>A0A0S2Z383
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NK2 homeobox 5 interacts with:

• calmodulin binding transcription activator 2
  EWS RNA binding protein 1
  F-box protein 25
  forkhead box A1
  forkhead box E1
  forkhead box H1
  GATA binding protein 4
  growth factor receptor bound protein 2
  histone deacetylase 1
  homeodomain interacting protein kinase 1
  homeodomain interacting protein kinase 2
  inhibitor of DNA binding 1, HLH protein
  inhibitor of DNA binding 2
  inhibitor of DNA binding 3, HLH protein
  jumonji and AT-rich interaction domain containing 2
  Jun proto-oncogene, AP-1 transcription factor subunit
  keratin associated protein 8-1
  lysine demethylase 6A
  recombination signal binding protein for immunoglobulin kappa J region
  RNA binding protein, mRNA processing factor
  serum response factor
  short stature homeobox
  SMAD family member 4
  T-box transcription factor 2
  T-box transcription factor 5
  thyroid hormone receptor interactor 10
  TLE family member 1, transcriptional corepressor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.