FASN, fatty acid synthase

FASN, fatty acid synthase

• The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

• Gene Synonyms (FAS, OA-519, SDR27X1, fatty acid synthase, short chain dehydrogenase/reductase family 27X, member 1,)
• NCBI Gene ID: 2194
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49327
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

fatty acid synthase interacts with:

• AAR2 splicing factor
  activator of HSP90 ATPase activity 1
  adiponectin, C1Q and collagen domain containing
  anoctamin 7
  anterior gradient 2, protein disulphide isomerase family member
  ataxin 3
  ATP binding cassette subfamily C member 1
  BCL2-associated athanogene 2
  chaperonin containing TCP1 subunit 6B
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 8
  cullin 3
  cullin 7
  cyclase associated actin cytoskeleton regulatory protein 1
  DDB1 and CUL4 associated factor 15
  defective in cullin neddylation 1 domain containing 1
  DExD-box helicase 39B
  DnaJ heat shock protein family (Hsp40) member C7
  dual specificity phosphatase 13
  dual specificity phosphatase 23
  dual specificity phosphatase 29
  dynamin 1 like
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  eukaryotic translation initiation factor 4A3
  expressed sequence AI837181
  fatty acid synthase
  F-box and WD repeat domain containing 8
  F-box protein 6
  F-box protein 7
  fibroblast growth factor 11
  fibronectin 1
  forkhead box I1
  forkhead box I2
  forkhead box L1
  FUS RNA binding protein
  glutamate rich WD repeat containing 1
  glutamine--fructose-6-phosphate transaminase 1
  glutamine-fructose-6-phosphate transaminase 2
  glycogen synthase kinase 3 beta
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  HAUS augmin like complex subunit 4
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  histone deacetylase 6
  HSPA (Hsp70) binding protein 1
  huntingtin
  hydroxysteroid 17-beta dehydrogenase 10
  hydroxysteroid 17-beta dehydrogenase 12
  hypoxia inducible factor 1 subunit alpha
  inosine monophosphate dehydrogenase 1
  integrin alpha FG-GAP repeat containing 1
  integrin linked kinase
  interferon regulatory factor 3
  interferon regulatory factor 7
  ISG15 ubiquitin like modifier
  junction plakoglobin
  keratin 17
  kinesin family member 11
  kinesin family member 3A
  lamin A/C
  leucine rich repeat containing G protein-coupled receptor 4
  ligand of numb-protein X 1
  limb development membrane protein 1 like
  lunapark, ER junction formation factor
  mago homolog, exon junction complex subunit
  metadherin
  methyltransferase like 3
  minichromosome maintenance complex component 2
  mitochondrial carrier 1
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase 3
  MYC proto-oncogene, bHLH transcription factor
  neurotrophic receptor tyrosine kinase 1
  neutrophil cytosolic factor 1
  nitric oxide synthase 2
  N-myc downstream regulated 1
  nuclear receptor subfamily 2 group C member 2
  nucleophosmin 1
  obscurin like cytoskeletal adaptor 1
  palmitoyl-protein thioesterase 1
  parkin RBR E3 ubiquitin protein ligase
  penta-EF-hand domain containing 1
  phosphatase and tensin homolog
  phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
  phosphoenolpyruvate carboxykinase 1
  phosphorylase kinase catalytic subunit gamma 2
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  prohibitin
  proline rich 12
  prostaglandin reductase 2
  protein phosphatase 6 catalytic subunit
  protein tyrosine phosphatase non-receptor type 11
  PTEN induced kinase 1
  pyruvate carboxylase
  pyruvate dehydrogenase E1 subunit alpha 1
  RAD21 cohesin complex component
  RecQ like helicase 4
  required for meiotic nuclear division 5 homolog A
  ring finger protein 4
  RIO kinase 1
  SHC adaptor protein 1
  shootin 1
  sirtuin 1
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  snail family transcriptional repressor 1
  SNW domain containing 1
  speckle type BTB/POZ protein
  spindle apparatus coiled-coil protein 1
  staufen double-stranded RNA binding protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  TAR (HIV-1) RNA binding protein 1
  TEA domain transcription factor 3
  thymopoietin
  TNFAIP3 interacting protein 2
  transcription factor CP2
  tripartite motif containing 28
  tropomyosin 3
  tropomyosin 4
  tubulin, gamma 1
  tumor protein p53 binding protein 1
  tumor susceptibility 101
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 18
  ubiquitin specific peptidase 2
  ubiquitin specific peptidase 22
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 7A
  zinc finger containing ubiquitin peptidase 1
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.