MAPT, microtubule associated protein tau

MAPT, microtubule associated protein tau

• This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, microtubule-associated protein tau, G protein beta1/gamma2 subunit-interacting factor 1, PHF-tau, neurofibrillary tangle protein, paired helical filament-tau, protein phosphatase 1, regulatory subunit 103,)
• NCBI Gene ID: 4137
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RA17
  UNIPROT ID#>>A0A024R9Y1
  UNIPROT ID#>>A0A024RA19
  UNIPROT ID#>>A0A024R9Y0
  UNIPROT ID#>>B3KTM0
  UNIPROT ID#>>P10636
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

microtubule associated protein tau interacts with:

• activator of HSP90 ATPase activity 1
  aminopeptidase puromycin sensitive
  apoptosis antagonizing transcription factor
  armadillo repeat containing 1
  ataxin 2
  BAG cochaperone 6
  BR serine/threonine kinase 1
  BR serine/threonine kinase 2
  cell division cycle 37, HSP90 cochaperone
  cell division cycle associated 8
  checkpoint kinase 2
  chromosome 19 open reading frame 53
  chromosome 7 open reading frame 50
  chromosome 9 open reading frame 78
  coiled-coil domain containing 124
  CUE domain containing 2
  cytoskeleton associated protein 5
  density regulated re-initiation and release factor
  dual specificity tyrosine phosphorylation regulated kinase 2
  dynein axonemal assembly factor 2
  dynein light chain roadblock-type 1
  elongin A
  endothelial differentiation related factor 1
  eukaryotic translation initiation factor 2 subunit beta
  ezrin
  G3BP stress granule assembly factor 1
  G3BP stress granule assembly factor 2
  GAR1 ribonucleoprotein
  general transcription factor II E, polypeptide 2 (beta subunit)
  glucosamine-phosphate N-acetyltransferase 1
  H1.10 linker histone
  HCLS1 associated protein X-1
  hepatocyte growth factor-regulated tyrosine kinase substrate
  heterogeneous nuclear ribonucleoprotein U like 1
  histone deacetylase 6
  hook microtubule tethering protein 3
  HtrA serine peptidase 1
  katanin catalytic subunit A1
  KIAA1143
  kinesin family member C3
  legumain
  leucine rich repeat kinase 2
  mannan binding lectin serine peptidase 1
  MAP7 domain containing 1
  maternal embryonic leucine zipper kinase
  membrane associated ring-CH-type finger 7
  methionyl aminopeptidase 2
  methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  microtubule affinity regulating kinase 1
  microtubule affinity regulating kinase 3
  microtubule affinity regulating kinase 4
  microtubule associated protein RP/EB family member 1
  microtubule associated protein tau
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 10
  mitogen-activated protein kinase 11
  mitogen-activated protein kinase 12
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase 3
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase 8 interacting protein 1
  mitogen-activated protein kinase 9
  mitogen-activated protein kinase kinase 7
  negative regulator of ubiquitin like proteins 1
  nicotinamide nucleotide adenylyltransferase 2
  NME/NM23 nucleoside diphosphate kinase 2
  N-myristoyltransferase 1
  NOP2/Sun RNA methyltransferase 2
  nuclear distribution C, dynein complex regulator
  nuclear FMR1 interacting protein 1
  O-linked N-acetylglucosamine (GlcNAc) transferase
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  parkin RBR E3 ubiquitin protein ligase
  paternally expressed 10
  PDGFA associated protein 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  phosphoinositide-3-kinase regulatory subunit 1
  phospholipase C gamma 1
  phospholipase C gamma 2
  phosphorylase kinase catalytic subunit gamma 1
  poly(A) binding protein cytoplasmic 1
  presenilin 1
  proliferation-associated 2G4
  prostaglandin E synthase 3
  proteasome 20S subunit beta 5
  proteasome 26S subunit, ATPase 2
  protein activator of interferon induced protein kinase EIF2AK2
  protein disulfide isomerase family A member 2
  protein kinase C alpha
  protein kinase C and casein kinase substrate in neurons 1
  protein kinase C beta
  protein kinase C delta
  protein kinase C epsilon
  protein kinase C gamma
  protein kinase C iota
  protein kinase C zeta
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase N1
  protein kinase, cAMP dependent, catalytic, alpha
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 catalytic subunit beta
  protein phosphatase 2 phosphatase activator
  protein phosphatase 2 regulatory subunit B'alpha
  protein phosphatase 5 catalytic subunit
  PWP2 small subunit processome component
  Rho guanine nucleotide exchange factor 40
  Rho/Rac guanine nucleotide exchange factor 2
  ribosomal protein L35
  ribosomal protein S26
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A3
  ribosomal protein S6 kinase A5
  ribosomal protein S6 kinase B1
  ribosomal RNA processing 7 homolog A
  RNA transcription, translation and transport factor
  S100 calcium binding protein B
  salt inducible kinase 1
  secretogranin III
  sequestosome 1
  SERPINE1 mRNA binding protein 1
  serum/glucocorticoid regulated kinase 1
  signal recognition particle 14
  sirtuin 1
  small nuclear ribonucleoprotein U1 subunit 70
  sodium channel and clathrin linker 1
  solute carrier family 1 member 2
  solute carrier family 6 (neurotransmitter transporter, creatine), member 8
  spectrin beta, erythrocytic
  spindle and centriole associated protein 1
  spleen associated tyrosine kinase
  SRC proto-oncogene, non-receptor tyrosine kinase
  SRSF protein kinase 1
  SRSF protein kinase 2
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  stress induced phosphoprotein 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  syntaxin binding protein 1
  synuclein alpha
  tau tubulin kinase 1
  TIA1 cytotoxic granule associated RNA binding protein
  tigger transposable element derived 6
  TNF receptor associated factor 6
  transcription factor EB
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin alpha 4a
  tubulin beta 3 class III
  tubulin beta class I
  tubulin, alpha 1A
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin B
  ubiquitin C
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 W
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 43
  ubiquitin specific peptidase 9 Y-linked
  Y-box binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.